3-(3-chloropropyl)-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
3-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one
CAS: 85175-59-3
Molecular Formula: C15H18ClNO3
3-(3-chloropropyl)-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one - Names and Identifiers
3-(3-chloropropyl)-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one - Physico-chemical Properties
| Molecular Formula | C15H18ClNO3 |
| Molar Mass | 295.76 |
| Density | 1.191±0.06 g/cm3(Predicted) |
| Melting Point | 100-102 °C(Solv: ethanol (64-17-5)) |
| Boling Point | 484.1±45.0 °C(Predicted) |
| Flash Point | 246.6°C |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 1.58E-09mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | -1.23±0.20(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Refractive Index | 1.544 |
3-(3-chloropropyl)-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one - Risk and Safety
| HS Code | 29339900 |
3-(3-chloropropyl)-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one - Reference Information
| Introduction | ivabradine hydrochloride side chain 3-(3-chloropropyl)-7, 8-dimethoxy-1, 3-dihydro-2h-3-benzoaza-2-one. Ivabradine and its pharmaceutically acceptable salts, especially its hydrochloride, have very important pharmacological and therapeutic properties, especially with the properties of slowing the heart rate, these compounds can thus be used for the treatment or prevention of various clinical conditions of myocardial ischemia, such as angina pectoris, myocardial infarction and related rhythm disorders, as well as various pathologies involving rhythm disorders, especially supraventricular rhythm disorders. |
| Application | ivabradine hydrochloride side chain is an organic compound that can be used as a pharmaceutical intermediate. |
| preparation method | 1.5g(6.8mmol) of 7, 8-dimethoxy-1, 3-dihydro-2h-3-benzoaza-2-one, 1.5g(9.5mmol) of 1, 3-bromochloropropane and 6mL of DMF were placed in a flask, the temperature of the reaction mixture was raised to 40 °c and a solution of 0.8g of 40% sodium hydroxide (8mmol) was added. The mixture was then heated to 60 °c and stirred for 2 hours; 30ml of ice-water was added and stirred for 1 hour under ice-water bath cooling. The solid precipitate was filtered off, washed and dried. The yield of the title compound obtained was 85%. |
Last Update：2024-04-09 21:04:16
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