3-(3-nitrophenyl)-2H-pyrazole-4-carboxaldehyde
3-(3-Nitrophenyl)-1H-pyrazole-4-carbaldehyde
CAS: 26033-25-0
Molecular Formula: C10H7N3O3
3-(3-nitrophenyl)-2H-pyrazole-4-carboxaldehyde - Names and Identifiers
3-(3-nitrophenyl)-2H-pyrazole-4-carboxaldehyde - Physico-chemical Properties
| Molecular Formula | C10H7N3O3 |
| Molar Mass | 217.18 |
| Density | 1.450±0.06 g/cm3(Predicted) |
| Melting Point | 156-158 °C(Solv: water (7732-18-5)) |
| Boling Point | 506.2±45.0 °C(Predicted) |
| pKa | 9.97±0.50(Predicted) |
| Storage Condition | Room Temprature |
| Sensitive | Irritant |
| MDL | MFCD05664577 |
3-(3-nitrophenyl)-2H-pyrazole-4-carboxaldehyde - Risk and Safety
| Hazard Class | IRRITANT |
3-(3-nitrophenyl)-2H-pyrazole-4-carboxaldehyde - Introduction
3-(3-Nitrophenyl)-1H-pyrazole-4-carbaldehyde is an organic compound with nitro and carbonyl functional groups. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 3-(3-Nitrophenyl)-1H-pyrazole-4-carbaldehyde is a yellow to orange crystalline solid.
-Melting point: Its melting point range is usually between 130-135 degrees Celsius.
-Solubility: It is better soluble in some organic solvents (such as ethanol, dichloromethane).
Use:
-Chemical reagent: 3-(3-nitrophenyl)-1H-pyrazole-4-carbaldehyde can be used as a reagent in organic synthesis, such as intermediates in the synthesis of other organic compounds or laboratory research.
-Drug research: Due to its special structure, it may have drug or biological activity and can be used in the field of drug research.
Preparation Method:
3-(3-Nitrophenyl)-1H-pyrazole-4-carbaldehyde can be synthesized by the following steps:
1.3-nitrobenzoic acid reacts with propylene glycol to generate 3-nitrophenyl malonic acid.
2.3-nitrophenyl malonic acid reacts with hydrazine to generate 3-(3-nitrophenyl)-1H-pyrazol-4-one.
3. Reduction of 3-(3-nitrophenyl)-1H-pyrazol-4-one to 3-(3-nitrophenyl)-1H-pyrazole-4-carbaldehyde.
Safety Information:
- 3-(3-nitrophenyl)-1H-pyrazole-4-carbaldehyde has limited safety and toxicity data, so care should be taken when using and handling it.
-It may cause irritation to the eyes, skin and respiratory tract, so wear appropriate personal protective equipment (such as gloves, goggles and masks).
-Avoid inhaling aerosols or dust during operation, and ensure that you operate in a well-ventilated area.
-If contact or ingestion occurs, medical advice should be obtained immediately and the packaging or label should be provided for reference.
Nature:
-Appearance: 3-(3-Nitrophenyl)-1H-pyrazole-4-carbaldehyde is a yellow to orange crystalline solid.
-Melting point: Its melting point range is usually between 130-135 degrees Celsius.
-Solubility: It is better soluble in some organic solvents (such as ethanol, dichloromethane).
Use:
-Chemical reagent: 3-(3-nitrophenyl)-1H-pyrazole-4-carbaldehyde can be used as a reagent in organic synthesis, such as intermediates in the synthesis of other organic compounds or laboratory research.
-Drug research: Due to its special structure, it may have drug or biological activity and can be used in the field of drug research.
Preparation Method:
3-(3-Nitrophenyl)-1H-pyrazole-4-carbaldehyde can be synthesized by the following steps:
1.3-nitrobenzoic acid reacts with propylene glycol to generate 3-nitrophenyl malonic acid.
2.3-nitrophenyl malonic acid reacts with hydrazine to generate 3-(3-nitrophenyl)-1H-pyrazol-4-one.
3. Reduction of 3-(3-nitrophenyl)-1H-pyrazol-4-one to 3-(3-nitrophenyl)-1H-pyrazole-4-carbaldehyde.
Safety Information:
- 3-(3-nitrophenyl)-1H-pyrazole-4-carbaldehyde has limited safety and toxicity data, so care should be taken when using and handling it.
-It may cause irritation to the eyes, skin and respiratory tract, so wear appropriate personal protective equipment (such as gloves, goggles and masks).
-Avoid inhaling aerosols or dust during operation, and ensure that you operate in a well-ventilated area.
-If contact or ingestion occurs, medical advice should be obtained immediately and the packaging or label should be provided for reference.
Last Update：2024-04-09 20:49:11
