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3-(4,5-Dimethylthiazolyl-2)-2,5-DIPHENYL TETRAZOLIUM BROMIDE

MTT

CAS: 298-93-1;2348-71-2

Molecular Formula: C18H16BrN5S

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  5. 3-(4,5-Dimethylthiazolyl-2)-2,5-DIPHENYL TETRAZOLIUM BROMIDE

3-(4,5-Dimethylthiazolyl-2)-2,5-DIPHENYL TETRAZOLIUM BROMIDE - Names and Identifiers

Name MTT
Synonyms MTT
MTT (1.11714)
Thiazolyl Blue
METHYLTHIAZOLETETRAZOLIUM
Thiazolyl Blue tetrazolium bromide
3-(4,5-Dimethyl-2-Thiazolyl)-2,5-Diphenyl
3-(4,5-Dimethyl-2-thizolyl)-2,5-diphenyltertazolium bromide
3,[4,5-Dimethylthiazol-2-YL]-2,5-DIPHENYLTETRAZOLIUM BROMIDE
2,5-diphenyl-3-(4,5-dimethylthiazol-2-yl)tetrazolium Bromide
3-(4,5-Dimethylthiazolyl-2)-2,5-DIPHENYL TETRAZOLIUM BROMIDE
3-(4,5-Dimethyl-2-THIAZOLYL)-2,5-DIPHENYLTETRAZOLIUM BROMIDE
3-(4,5-Dimethylthiazol-2-YL)-2,5-DIPHYL-2 H-TETRAZOLIUM BROMIDE
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2h-tetrazoliumbromide
2,5-diphenyl-3-(4,5-dimethylthiazol-2-yl)-2h-tetrazolium Bromide
3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide
3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide
3-(4,5-DIMETHYLITHIAZOLYL-2)-2,5-DIPHENYL MONOTETRAZOLIUM BROMIDE
3-(4,5-Dimethyl-2-THIAZOL-2-YL)-2,5-DIPHENYL-2H-TETRAZOLIUM BROMIDE
2-(4,5-Dimethyl-2-thiazolyl)-3,5-diphenyl-2H-tetrazol-3-ium Bromide
3-(4,5-dimethyl-1,3-thiazol-2-yl)-2,5-diphenyl-2H-tetrazol-3-ium bromide
3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl-2,3-dihydro-1H-tetrazol-3-ium bromide
2-(4,5-Dimethylthiazol-2-yl)-3,5-diphenyl-2,3-dihydro-1H-tetrazol-3-ium bromide
3-(4,5-dimethyl-1,3-thiazol-2-yl)-2,5-diphenyl-2,3-dihydro-1H-tetrazol-1-ium bromide
CAS 298-93-1
2348-71-2
EINECS 206-069-5
InChI InChI=1/C18H17N5S.BrH/c1-13-14(2)24-18(19-13)23-21-17(15-9-5-3-6-10-15)20-22(23)16-11-7-4-8-12-16;/h3-12H,1-2H3,(H,20,21);1H
InChIKey AZKSAVLVSZKNRD-UHFFFAOYSA-M

3-(4,5-Dimethylthiazolyl-2)-2,5-DIPHENYL TETRAZOLIUM BROMIDE - Physico-chemical Properties

Molecular FormulaC18H16BrN5S
Molar Mass414.32
Density1.4886 (estimate)
Melting Point195 °C (dec.) (lit.)
Water SolubilitySlightly soluble.Clear yellow solution at 5mg in 1ml of water on vortexing
Solubility Slightly soluble in methanol, but hardly soluble in water or ethanol. It cannot be completely dissolved with ether, acetone or ethyl acetate.
AppearancePale yellow or yellow powder or orange yellow powder
ColorYellow to orange
Maximum wavelength(λmax)['378 nm, 242 nm']
BRN3825277
Storage Condition2-8°C
StabilityHygroscopic
SensitiveLight Sensitive
MDLMFCD00011964
UseThis product is for scientific research only and shall not be used for other purposes.
In vitro study Thiazolyl Blue (MTT) is used in conjunction with rhodamine B to measure mitochondrial membrane potential. Thiazolyl Blue-formazan is generated in mitochondria acts as a fluorescence quencher for rhodamine that distributes across membranes of viable cells according to membrane potential. In the absence of mPMS, cellular reduction of Thiazolyl Blue is strong. Thiazolyl Blue is membrane-impermeable when incorporated into large unilamellar liposomes, and therefore it is taken up by cells via endocytosis.

3-(4,5-Dimethylthiazolyl-2)-2,5-DIPHENYL TETRAZOLIUM BROMIDE - Risk and Safety

Risk CodesR46 - May cause heritable genetic damage
R68 - Possible risk of irreversible effects
R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety DescriptionS22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S53 - Avoid exposure - obtain special instructions before use.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37 - Wear suitable protective clothing and gloves.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany3
RTECSXF8060000
FLUKA BRAND F CODES3-8-10
TSCAYes
HS Code29341000

3-(4,5-Dimethylthiazolyl-2)-2,5-DIPHENYL TETRAZOLIUM BROMIDE - Introduction

It is commonly used to detect cell viability, cell proliferation or cytotoxicity based on MTT detection methods. Because MTT has a positive charge, it can pass through the cell membrane and be reduced by mitochondria to form a purple nail dye. Organic solvents are required to dissolve MTT methyl dye. Dehydrogenase detection, determination of enzyme activity in biochemical research, determination of NADH2, NADPH2 and myocardial yellow enzyme (Diaphorase).
Last Update：2022-10-16 17:24:22

3-(4,5-Dimethylthiazolyl-2)-2,5-DIPHENYL TETRAZOLIUM BROMIDE - Reference Information

biological field application Cell viability say; microbial growth assays; DNA quantification assays; tissue viability assays; detecting enzymes; measuring membrane potential; treating Alzheimer's disease,asthma,cancer
EPA chemical information Information provided by: ofmpub.epa.gov (external link)
Biological activity Thiazolyl Blue (MTT, Tetrazolium bromide, Methylthiazolyldiphenyl-tetrazolium bromide, Methylthialazole Tetrazolium) is a cell permeable and positively charged colorimetric agent, It is widely used to detect reducing metabolism in cells and measure cell proliferation, cytotoxicity and apoptosis. Thiazolyl Blue (MTT) will be reduced from yellow to purple in living cells.
use 1. determination of cytotoxicity of drugs (including other treatment methods such as radiation irradiation) on in vitro culture; 2. determination of cell proliferation and cell activity.
toxic substance data information provided by: pubchem.ncbi.nlm.nih.gov (external link)
Last Update：2024-04-10 22:29:15
3-(4,5-Dimethylthiazolyl-2)-2,5-DIPHENYL TETRAZOLIUM BROMIDE
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View History
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