3-(4-氯-1-氧代丁基)-1H-吲哚-5-甲腈

3-(4-氯-1-氧代丁基)-1H-吲哚-5-甲腈 - Names and Identifiers

Name	3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
Synonyms	Vilazodone Intermediate 6 3-(4-chlorobutyryl)-5-cyanoindole 3-(4-chlorobutanoyl)-1H-indole-5-carboni 3-(4-Chloro-1-oxobutyl)indole-5-carbonitrile 3-(4-Chlorobutyryl)-1H-Indole-5-Carbonitrile 3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile 3-(4-Chloro-1-oxobutyl)-1H-indole-5-carbonitrile 3-(4-chloro-1-oxobutyl)-1H-indole-5-carbonitrile 1H-Indole-5-carbonitrile, 3-(4-chloro-1-oxobutyl)-
CAS	276863-95-7
EINECS	1806241-263-5

3-(4-氯-1-氧代丁基)-1H-吲哚-5-甲腈 - Physico-chemical Properties

Molecular Formula	C13H11ClN2O
Molar Mass	246.69
Density	1.31
Melting Point	169-170 °C
Boling Point	489.9±35.0 °C(Predicted)
Solubility	Dimethyl Sulfoxide, Hot Methanol
Appearance	Solid
Color	Light Green
pKa	14.07±0.30(Predicted)
Storage Condition	2-8°C
Use	This product is for scientific research only and shall not be used for other purposes.

3-(4-氯-1-氧代丁基)-1H-吲哚-5-甲腈 - Introduction

3-(4-chlorobutanoyl)-1h-indole-5-carbonitril is an organic compound with the chemical formula C13H11ClN2O. The following is a description of the properties, uses, preparation and safety information of the compound:

Properties: 3-(4-chlorobutanoyl)-1h-indole-5-carbonitril is a colorless to light yellow crystalline solid. The compound is stable at room temperature, but may decompose under high temperature or light. It has low solubility in solvents and is soluble in organic solvents such as chloroform and ether.

Use: This compound is often used as a pharmaceutical intermediate. It can be used to synthesize a variety of biologically active compounds, such as anti-cancer drugs, anti-inflammatory drugs and so on.

Preparation method: The synthesis method of 3-(4-chlorobutanoyl)-1h-indole-5-carbonitril is usually realized by chemical reaction. A common preparation method is to react 1H-indole -5-carboxylic acid with 4-chlorobutyric anhydride to produce 3-(4-chloro-1-oxobutyl)-1H-indole-5-carboxylic anhydride, which is then reacted with sodium cyanide to produce the desired product.

Safety information: For the use of chemicals should follow the appropriate safety procedures. This compound may be toxic to humans, so it should be handled under well-ventilated conditions and avoid contact with skin, eyes and inhalation of its dust. Appropriate personal protective equipment, such as lab gloves and safety glasses, should be worn during use.

Last Update：2024-04-09 20:49:11