3-(Difluoromethoxy)aniline
3-(difluoromethoxy)aniline
CAS: 22236-08-4
Molecular Formula: C7H7F2NO
3-(Difluoromethoxy)aniline - Names and Identifiers
| Name | 3-(difluoromethoxy)aniline |
| Synonyms | BUTTPARK 45 3-43 3-Difluoromethoxy aniline 3-(DIFLUOROMETHOXY)ANILINE 3-(Difluoromethoxy)aniline 3-(difluoromethoxy)aniline 3-Difluoromethoxy-phenylamine ALPHA,ALPHA-DIFLUORO-M-ANISIDINE 3-AMINO-ALPHA,ALPHA-DIFLUOROANISOLE 3-Amino-alpha,alpha-difluoroanisole alpha,alpha-Difluoro-m-anisidine |
| CAS | 22236-08-4 |
| InChI | InChI=1/C7H7F2NO/c8-7(9)11-6-3-1-2-5(10)4-6/h1-4,7H,10H2 |
3-(Difluoromethoxy)aniline - Physico-chemical Properties
| Molecular Formula | C7H7F2NO |
| Molar Mass | 159.13 |
| Density | 1.276 g/mL at 25 °C (lit.) |
| Boling Point | 201-202 °C (lit.) |
| Flash Point | 225°F |
| Vapor Presure | 0.0672mmHg at 25°C |
| Appearance | Liquid |
| Color | Colorless to pale yellow |
| pKa | 3?+-.0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Sensitive | Air Sensitive |
| Refractive Index | n20/D 1.5100(lit.) |
| MDL | MFCD00236221 |
3-(Difluoromethoxy)aniline - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29222990 |
| Hazard Note | Toxic |
3-(Difluoromethoxy)aniline - Introduction
3-(difluoromethoxy)aniline is an organic compound with the chemical formula C7H6F2NO. The following is an introduction to its nature, use, preparation and safety information:
Nature:
-Appearance: 3-(difluoromethoxy)aniline is a colorless or light yellow liquid.
-Melting point: About -3.5 ℃.
-Boiling point: About 185 ℃.
-Density: about 1.25 g/mL.
-Solubility: Soluble in organic solvents, such as ethanol, methanol and dichloromethane.
Use:
- 3-(difluoromethoxy)aniline is an intermediate in organic synthesis. It can be used to synthesize pharmaceutically active or other organic compounds.
-It can also be used as a precursor for dyes and labeling reagents.
Method:
- 3-(difluoromethoxy)aniline can be prepared by reacting 3-bromoaniline with difluormethanol. The reaction needs to be carried out under basic conditions.
Safety Information:
- 3-(difluoromethoxy)aniline is generally stable and relatively safe under normal conditions of use, but the following matters still need to be paid attention:
-May be slightly irritating. After contact with skin and eyes, rinse immediately with water.
-Do not ingest or inhale. If this happens, medical help should be sought immediately.
-Wear appropriate personal protective equipment such as lab coats, glasses and gloves during use.
In General, 3-(difluoromethoxy)aniline is a commonly used organic synthesis intermediate, which has certain application value, but it is necessary to pay attention to safe operation when using it.
Nature:
-Appearance: 3-(difluoromethoxy)aniline is a colorless or light yellow liquid.
-Melting point: About -3.5 ℃.
-Boiling point: About 185 ℃.
-Density: about 1.25 g/mL.
-Solubility: Soluble in organic solvents, such as ethanol, methanol and dichloromethane.
Use:
- 3-(difluoromethoxy)aniline is an intermediate in organic synthesis. It can be used to synthesize pharmaceutically active or other organic compounds.
-It can also be used as a precursor for dyes and labeling reagents.
Method:
- 3-(difluoromethoxy)aniline can be prepared by reacting 3-bromoaniline with difluormethanol. The reaction needs to be carried out under basic conditions.
Safety Information:
- 3-(difluoromethoxy)aniline is generally stable and relatively safe under normal conditions of use, but the following matters still need to be paid attention:
-May be slightly irritating. After contact with skin and eyes, rinse immediately with water.
-Do not ingest or inhale. If this happens, medical help should be sought immediately.
-Wear appropriate personal protective equipment such as lab coats, glasses and gloves during use.
In General, 3-(difluoromethoxy)aniline is a commonly used organic synthesis intermediate, which has certain application value, but it is necessary to pay attention to safe operation when using it.
Last Update：2024-04-09 15:17:56
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