3-ABA
m-aminobenzamide
CAS: 3544-24-9
Molecular Formula: C7H8N2O
3-ABA - Names and Identifiers
| Name | m-aminobenzamide |
| Synonyms | 3-ABA INO1001 INO 1001 3544-24-9 3-aminobenzamide m-aminobenzamide 3-AMINOBENZAMIDE M-AMINOBENZAMIDE Benzamide, 3-amino- PARP Inhibitor I, 3-ABA INO-1001(3-Aminobenzamide |
| CAS | 3544-24-9 |
| EINECS | 222-586-9 |
| InChI | InChI=1/C7H8N2O/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H2,9,10) |
3-ABA - Physico-chemical Properties
| Molecular Formula | C7H8N2O |
| Molar Mass | 136.15 |
| Density | 1.1778 (rough estimate) |
| Melting Point | 115-116 °C (lit.) |
| Boling Point | 250.42°C (rough estimate) |
| Flash Point | 153.2°C |
| Water Solubility | Soluble in dimethylformamide (~30 mg/ml), dimethyl sulfoxide (~30 mg/ml), phosphate buffered saline (pH7.2) (~2 mg/ml), water (25 mg/ml), and ethanol (25 mg/ml). |
| Solubility | ethanol: 50mg/mL, clear, faintly yellow |
| Vapor Presure | 0.000175mmHg at 25°C |
| Appearance | powder |
| Color | white to off-white |
| BRN | 2802373 |
| pKa | 16.26±0.50(Predicted) |
| Storage Condition | room temp |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| Sensitive | Light Sensitive |
| Refractive Index | 1.5769 (estimate) |
| MDL | MFCD00007989 |
| Physical and Chemical Properties | White powder, melting point 115-117 °c. |
| In vitro study | 3-Aminobenzamide (PARP-IN-1) (>1 μM) causes more than 95% inhibition of PARP activity without significant cellular toxicity. INO-1001 significantly sensitizes CHO cells by blocking most of the DNA repair occurring between radiation fractions.3-Aminobenzamide significantly improves endothelial function by enhancing the acetylcholine-induced, endothelium-dependent, nitric oxide mediated vasorelaxation after exposure with 400 μM H 2 O 2 . |
| In vivo study | In a db/db (Lepr db/db ) mouse model, 3-Aminobenzamide ameliorates diabetes-induced albumin excretion and mesangial expansion, and also decreases diabetes-induced podocyte depletion. 3-Aminobenzamide (1.6 mg/kg via intracerebral injection) prevents NAD + depletion and improves water maze performance after controlled cortical impact (CCI) in mice. |
3-ABA - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| UN IDs | 3077 |
| WGK Germany | 3 |
| RTECS | CU8992000 |
| HS Code | 29242990 |
3-ABA - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| biological activity | 3-Aminobenzamide (3-ABA , 3-Amino Benzamide, 3-AB) is an effective Poly(ADP-ribose)polymerase (PARP) inhibitors can also inhibit apoptosis after SCI spinal cord injury in a caspase-independent manner. |
| Target | Value |
| use | organic chemical raw material intermediates. |
| category | toxic substances |
| toxicity classification | poisoning |
| acute toxicity | oral-wild bird LD50: 1000 mg/kg |
| flammability hazard characteristics | combustible; combustion produces toxic nitrogen oxide smoke |
| storage and transportation characteristics | warehouse ventilation and low temperature drying |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, mist water |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 02:00:08
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Spot supply
Product Name: 3-Aminobenzamide Visit Supplier Webpage Request for quotationCAS: 3544-24-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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