3-AMINO-5-(4-BROMOPHENYL)ISOXAZOLE
3-氨基-5-(4-溴苯基)异噁唑
CAS: 6525-98-0
Molecular Formula: C9H7BrN2O
3-AMINO-5-(4-BROMOPHENYL)ISOXAZOLE - Names and Identifiers
| Name | 3-氨基-5-(4-溴苯基)异噁唑 |
| Synonyms | 5-(4-BROMOPHENYL)ISOXAZOL-3-AMINE 3-AMINO-5-(4-BROMOPHENYL)ISOXAZOLE 3-Isoxazolamine, 5-(4-bromophenyl)- |
| CAS | 6525-98-0 |
3-AMINO-5-(4-BROMOPHENYL)ISOXAZOLE - Physico-chemical Properties
| Molecular Formula | C9H7BrN2O |
| Molar Mass | 239.07 |
| Density | 1.602±0.06 g/cm3(Predicted) |
| Melting Point | 144-148 °C |
| Boling Point | 426.4±35.0 °C(Predicted) |
| pKa | 1.93±0.10(Predicted) |
3-AMINO-5-(4-BROMOPHENYL)ISOXAZOLE - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
3-AMINO-5-(4-BROMOPHENYL)ISOXAZOLE - Introduction
3-Amino -5-(4-bromophenyl) isoxazole is an organic compound with the formula C8H7BrN4O. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: 3-amino -5-(4-bromophenyl) isoxazole as a white solid.
-Melting point: Its melting point is about 188-191 degrees Celsius.
-Solubility: The compound is soluble in some organic solvents, such as dimethyl sulfoxide (DMSO), dichloromethane, etc.
Use:
-Pharmaceutical field: 3-amino -5-(4-bromophenyl) isoxazole is an important pharmaceutical intermediate, used to synthesize some biologically active compounds, such as antibacterial drugs and anti-tumor drugs Wait.
Preparation Method:
- 3-amino -5-(4-bromophenyl) isoxazole can be synthesized by a variety of methods.
-A commonly used preparation method is to react 2-bromo-4-nitrobenzene with sodium hydroxide to generate 4-nitrophenol, and then to generate 4-methyl-2-nitrobenzene through ortho-methylation. Next, 4-methyl -2-nitrobenzene is reacted with 3-aminooxazole, followed by hydrogenation reduction and bromination to obtain the target product.
Safety Information:
- 3-amino -5-(4-bromophenyl) isoxazole is a chemical that requires safe handling.
-During use or storage, avoid contact with strong oxidants, avoid inhalation of powders or solutions, and avoid skin contact and intake.
-If you accidentally come into contact with the compound, flush the affected area with plenty of water in time and seek advice from your doctor.
-Wear appropriate personal protective equipment such as lab gloves, goggles and lab coats during operation.
-Please follow the relevant safety procedures and follow the instructions in the Chemical Safety Data Sheet (MSDS).
Nature:
-Appearance: 3-amino -5-(4-bromophenyl) isoxazole as a white solid.
-Melting point: Its melting point is about 188-191 degrees Celsius.
-Solubility: The compound is soluble in some organic solvents, such as dimethyl sulfoxide (DMSO), dichloromethane, etc.
Use:
-Pharmaceutical field: 3-amino -5-(4-bromophenyl) isoxazole is an important pharmaceutical intermediate, used to synthesize some biologically active compounds, such as antibacterial drugs and anti-tumor drugs Wait.
Preparation Method:
- 3-amino -5-(4-bromophenyl) isoxazole can be synthesized by a variety of methods.
-A commonly used preparation method is to react 2-bromo-4-nitrobenzene with sodium hydroxide to generate 4-nitrophenol, and then to generate 4-methyl-2-nitrobenzene through ortho-methylation. Next, 4-methyl -2-nitrobenzene is reacted with 3-aminooxazole, followed by hydrogenation reduction and bromination to obtain the target product.
Safety Information:
- 3-amino -5-(4-bromophenyl) isoxazole is a chemical that requires safe handling.
-During use or storage, avoid contact with strong oxidants, avoid inhalation of powders or solutions, and avoid skin contact and intake.
-If you accidentally come into contact with the compound, flush the affected area with plenty of water in time and seek advice from your doctor.
-Wear appropriate personal protective equipment such as lab gloves, goggles and lab coats during operation.
-Please follow the relevant safety procedures and follow the instructions in the Chemical Safety Data Sheet (MSDS).
Last Update：2024-04-09 15:18:08
