3-AMINOISOXAZOLE
3-aminoisoxazole
CAS: 1750-42-1;36216-80-5
Molecular Formula: C3H4N2O
3-AMINOISOXAZOLE - Names and Identifiers
| Name | 3-aminoisoxazole |
| Synonyms | 3-aminoisoxazole 3-Amineisoxazole ISOXAZOL-3-AMINE 3-AMINOISOXAZOLE 3-amino isoxazole 1,2-oxazol-3-amine 1,2-benzisoxazol-3-amine 3-Aminoisoxazole3-Isoxazolamine Isoxazol-3-amine, 1,2-Oxazol-3-amine, 3-Amino-1,2-oxazole |
| CAS | 1750-42-1 36216-80-5 |
| EINECS | 605-748-7 |
| InChI | InChI=1/C7H6N2O/c8-7-5-3-1-2-4-6(5)10-9-7/h1-4H,(H2,8,9) |
| InChIKey | RHFWLPWDOYJEAL-UHFFFAOYSA-N |
3-AMINOISOXAZOLE - Physico-chemical Properties
| Molecular Formula | C3H4N2O |
| Molar Mass | 84.08 |
| Density | 1.138g/mLat 25°C(lit.) |
| Melting Point | 148-150 °C(Solv: ethyl ether (60-29-7); ligroine (8032-32-4)) |
| Boling Point | 226-228°C(lit.) |
| Flash Point | >230°F |
| Vapor Presure | 0.000559mmHg at 25°C |
| Appearance | Liquid |
| Color | Clear yellow |
| pKa | 2.27±0.10(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| Refractive Index | n20/D 1.511(lit.) |
| Use | 3-Aminoisoxazole is an organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process. |
3-AMINOISOXAZOLE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R37/38 - Irritating to respiratory system and skin. R36 - Irritating to the eyes |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| HS Code | 29349990 |
| Hazard Note | Irritant |
3-AMINOISOXAZOLE - A preparation method of 3-aminoisoxazole
Patent type: invention patent
Application (patent) No.: cn202011109306.2
Application date: 20201016
Publication / Announcement No.: cn112047897a
Date of Publication / announcement: 20201208
Applicant (patentee): Yangzhou Tianhe Pharmaceutical Co., Ltd
Country / Province Code: cn321012
Summary:
The invention belongs to the technical field of medicine, in particular to a preparation method of 3-aminoisoxazole:
(1) Preparation of 2,3 dichloropropionitrile: put acrylonitrile, N, n dimethylformamide and pyridine into the reaction vessel, reduce the temperature to 5 ~ 15 ℃, fill the reaction vessel with chlorine and maintain the reaction temperature of 1020 ℃; After chlorine gas is introduced, the temperature is controlled at 15 ~ 25 ℃ and stirred for 5 hours; Blow out excess chlorine until the reaction solution is yellowish or colorless and transparent to obtain 2,3 dichloropropiononitrile
(2) Preparation of 3-aminoisoxazole: under alkaline conditions, 3-aminoisoxazole was synthesized from hydroxyurea and 2,3-dichloropropiononitrile with N, N-dimethylformamide as catalyst The invention is used to solve the technical problem that the preparation of 3-aminoisoxazole adopts 2,3 dibromo propionitrile intermediate, resulting in extremely easy blanking and high process risk
Last Update：2024-01-02 23:10:35
3-AMINOISOXAZOLE - Preparation of 5-substituted-3-aminoisoxazole compounds
Application (patent) No.: cn 200410017060
Date of application: Mar 19, 2004
Publication / Announcement No.: cn 1562985 a
Applicant (patentee): Shanghai Institute of Optics and precision machinery, Chinese Academy of Sciences
Country / Province Code: Shanghai
Summary:
The invention relates to a preparation method of 5-substituted-3-aminoisoxazole compound. The compound has the following general structural formula: in the structural formula, n represents nitrogen, C represents carbon, and R represents 1-4 alkyl groups
The preparation method is to first react the substituted acetylacetonitrile with hydroxylamine hydrochloride under weak alkaline conditions to obtain the mixture of aminooxime and the by-product 5-amino-3-substituted isoxazole compound, then remove the by-product by solvent extraction, the aminooxime cyclizes under the action of weak acid, and finally obtain the high-purity 5-substituted-3-amino-isoxazole compound
Last Update：2024-01-02 23:10:35
3-AMINOISOXAZOLE - Reference Information
| application | 3-aminoisoxazole is an organic synthesis intermediate and a pharmaceutical intermediate, which is mainly used in laboratory research and development and chemical production. |
Last Update：2024-04-09 02:00:07
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