3-Borono-5-fluoro-6-methoxypyridine

3-Borono-5-fluoro-6-methoxypyridine - Names and Identifiers

Name	(5-fluoro-6-methoxy-3-pyridyl)boronic acid
Synonyms	3-Borono-5-fluoro-6-methoxypyridine 5-Fluoro-6-methoxy-3-pyridineboronicacid 5-Fluoro-6-methoxypyridine-3-boronic acid 5-Fluoro-6-methoxy-3-pyridineboronic acid (5-fluoro-6-methoxy-3-pyridyl)boronic acid (5-fluoro-6-Methoxy-3-pyridyl)boronic acid Boronic acid, B-(5-fluoro-6-Methoxy-3-pyridinyl)- (5-Fluoro-6-methoxypyridin-3-yl)boronic Acid (contains varying amounts of Anhydride)
CAS	856250-60-7
InChI	InChI=1/C6H7BFNO3/c1-12-6-5(8)2-4(3-9-6)7(10)11/h2-3,10-11H,1H3

3-Borono-5-fluoro-6-methoxypyridine - Physico-chemical Properties

Molecular Formula	C6H7BFNO3
Molar Mass	170.93
Density	1.34
Boling Point	308.3±52.0 °C(Predicted)
Flash Point	140.2°C
Vapor Presure	0.000298mmHg at 25°C
Appearance	powder to crystal
Color	White to Almost white
pKa	6.21±0.11(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.502

3-Borono-5-fluoro-6-methoxypyridine - Introduction

boronic acid is an organic compound whose chemical formula is C6H7BFNO3. The following is a detailed description of its nature, use, preparation and safety information:

Nature:
boronic acid is a white to pale yellow solid. It is stable at room temperature and has low solubility in water. It can be moderately soluble in some organic solvents, such as dimethyl sulfoxide (DMSO), dimethylformamide (DMF) and acetonitrile. It has high thermal stability.

Use:
boronic acid is widely used in the field of organic synthesis. It is usually used as an important organoboron reagent for Palladium-catalyzed cross-coupling reactions, such as Suzuki coupling, Stille coupling and Negishi coupling. In addition, it can also be used in the synthesis of synthetic drugs, natural products and other organic molecules.

Preparation Method:
(br) boronic acid is synthesized by various methods. One common method is to react 3-fluoro-5-methoxypyridine with triphenylboronic acid or trimethylamide boronic acid by heating to produce the desired product. The product can be obtained by crystallization or column chromatography purification.

Safety Information:
There is currently limited safety information regarding the boronic acid. However, as an organic compound, it should be considered as a potentially hazardous substance. During operation and use, basic laboratory safety regulations must be observed, such as wearing appropriate personal protective equipment (gloves, glasses, etc.), avoiding skin contact and inhalation. In handling or disposal, local codes and regulations should be followed. Before use, it is recommended to contact the chemical supplier for more detailed safety information.

Last Update：2024-04-09 21:54:55