3-Bromo-2-chloropyridine

Name	2-Chloro-3-Bromo Pyridine
Synonyms	TIMTEC-BB SBB003618 OTAVA-BB BB7110952626 2-CHLORO-3-BROMOPYRIDINE 3-Bromo-2-chloropyridine 2-Chloro-3-bromopyridine 3-bromo-2-chloropyridine 3-Bromo-2-chlorolpyridine bromo-3 chloro-2 pyridine 2-Chloro-3-Bromo Pyridine 3-broMo -2-chlorine pyridine 2 - chloro - 3 - broMide pyridine
CAS	52200-48-3
EINECS	629-254-6
InChI	InChI=1/C5H3BrClN/c6-4-2-1-3-8-5(4)7/h1-3H

Molecular Formula	C5H3BrClN
Molar Mass	192.44
Density	1.7783 (rough estimate)
Melting Point	54-57 °C (lit.)
Boling Point	97 °C / 10mmHg
Flash Point	86.8°C
Vapor Presure	0.173mmHg at 25°C
Appearance	Pale yellow red solid
Color	White to yellow
BRN	109812
pKa	-0.63±0.10(Predicted)
Storage Condition	Inert atmosphere,Room Temperature
Refractive Index	1.5400 (estimate)
MDL	MFCD00234007

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany	3
HS Code	29339900
Hazard Class	IRRITANT

introduction	3-bromo -2-chloropyridine is white to yellow-white powder. it has been reported in the literature that it can be prepared from 3-amino -2-chloropyridine by diazotization reaction or from 2-chloropyridine -3-carboxylic acid, 2, 3-dibromopyridine is prepared by one-step reaction.
use	3-bromo -2-chloropyridine is a pyridine organic substance and can be used as an organic intermediate.
preparation	at room temperature, add water (45ml) and 48% hydrobromic acid (27ml) to 3-amino -2-chloropyridine (2.57g,20mmol). At room temperature, 2,2,6, 6-tetramethylpiperidine 1-oxyl (0.31g,2mmol) was added to the mixed solution, and the mixture was cooled to 10°C or lower. Then, sodium nitrite (4.14g) dissolved in water (30ml) was added to it. After stirring at room temperature for about 2 hours, 10mol/L aqueous sodium hydroxide solution (40ml) was added to it, followed by extraction with toluene (300ml) twice. Combine each toluene layer and wash with water (50ml). The solvent was distilled out by concentrating the toluene layer under reduced pressure to give 3-bromo-2-chloropyridine (7)(3.08g,80.1%).

Last Update：2024-04-09 21:11:58

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