3-Bromo-5-nitro-1H-indazole
3-bromo-5-nitro-2H-indazole
CAS: 67400-25-3
Molecular Formula: C7H4BrN3O2
3-Bromo-5-nitro-1H-indazole - Names and Identifiers
| Name | 3-bromo-5-nitro-2H-indazole |
| Synonyms | 5-NITRO-3-BROMOINDAZOLE 3-BROMO-5-NITROINDAZOLE 3-Bromo-5-nitro-1H-indazole 3-bromo-5-nitro-2H-indazole 3-BROMO-5-NITRO (1H)INDAZOLE 1H-indazole, 3-bromo-5-nitro- 1H-Indazole, 3-bromo-5-nitro- |
| CAS | 67400-25-3 |
| InChI | InChI=1/C7H4BrN3O2/c8-7-5-3-4(11(12)13)1-2-6(5)9-10-7/h1-3H,(H,9,10) |
3-Bromo-5-nitro-1H-indazole - Physico-chemical Properties
| Molecular Formula | C7H4BrN3O2 |
| Molar Mass | 242.03 |
| Density | 1.965±0.06 g/cm3(Predicted) |
| Melting Point | 227-229 |
| Boling Point | 437.3±25.0 °C(Predicted) |
| Flash Point | 109.2°C |
| Vapor Presure | 0.0149mmHg at 25°C |
| Appearance | Crystalline powder |
| Color | Pale brown |
| pKa | 9.53±0.40(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.763 |
| MDL | MFCD07367964 |
3-Bromo-5-nitro-1H-indazole - Risk and Safety
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN2811 |
| Hazard Class | IRRITANT |
3-Bromo-5-nitro-1H-indazole - Introduction
It is an organic compound. Its molecular formula is C7H4BrN3O2 and its relative molecular mass is 232.03g/mol. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: Light yellow crystal or powder.
-Melting point: about 210-214°C.
-Solubility: It has good solubility in organic solvents such as anhydrous ethanol and dimethyl sulfoxide, and is slightly soluble in water.
Use:
It is often used as an intermediate in organic synthesis. Its chemical structure contains nitro and bromine groups, and their introduction can open up new possibilities for the synthesis of new compounds. It also has applications in areas such as pharmaceutical research and pesticide synthesis.
Preparation Method: There are many preparation methods of
, one of the commonly used methods is obtained by nitration and bromination reaction of indazole ring. Specific steps are as follows:
1. Indazole is reacted with concentrated nitric acid for nitration to obtain 5-nitroindazole.
2. react 5-nitroindazole with sodium acetate and hydrogen bromide to carry out bromination reaction to obtain fluorene.
Safety Information:
-should be used in the laboratory and in accordance with safety procedures.
-It may be irritating and damaging to the skin, eyes and respiratory system, so you should wear appropriate protective equipment, avoid contact with skin and eyes, and maintain good ventilation.
-When handling and storing compounds, care should be taken to avoid mixing with combustibles and oxidants to prevent the risk of fire and explosion.
-Observe local regulations and safe practices when handling and disposing.
Nature:
-Appearance: Light yellow crystal or powder.
-Melting point: about 210-214°C.
-Solubility: It has good solubility in organic solvents such as anhydrous ethanol and dimethyl sulfoxide, and is slightly soluble in water.
Use:
It is often used as an intermediate in organic synthesis. Its chemical structure contains nitro and bromine groups, and their introduction can open up new possibilities for the synthesis of new compounds. It also has applications in areas such as pharmaceutical research and pesticide synthesis.
Preparation Method: There are many preparation methods of
, one of the commonly used methods is obtained by nitration and bromination reaction of indazole ring. Specific steps are as follows:
1. Indazole is reacted with concentrated nitric acid for nitration to obtain 5-nitroindazole.
2. react 5-nitroindazole with sodium acetate and hydrogen bromide to carry out bromination reaction to obtain fluorene.
Safety Information:
-should be used in the laboratory and in accordance with safety procedures.
-It may be irritating and damaging to the skin, eyes and respiratory system, so you should wear appropriate protective equipment, avoid contact with skin and eyes, and maintain good ventilation.
-When handling and storing compounds, care should be taken to avoid mixing with combustibles and oxidants to prevent the risk of fire and explosion.
-Observe local regulations and safe practices when handling and disposing.
Last Update：2024-04-09 20:44:15
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