3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine
3-chloro-2-fluoro-5-(trifluoromethyl)-pyridine
CAS: 72537-17-8
Molecular Formula: C6H2ClF4N
3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine - Names and Identifiers
3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine - Physico-chemical Properties
| Molecular Formula | C6H2ClF4N |
| Molar Mass | 199.53 |
| Density | 1.524 g/mL at 25 °C (lit.) |
| Melting Point | 16-20 °C (lit.) |
| Boling Point | 50-55 °C/11 mmHg (lit.) |
| Flash Point | 125°F |
| Vapor Presure | 3.944mmHg at 25°C |
| Appearance | Liquid |
| Color | Colorless |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | n20/D 1.433(lit.) |
3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R10 - Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| HS Code | 29333990 |
| Hazard Note | Irritant |
| Hazard Class | 3.2 |
| Packing Group | III |
3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine - Introduction
3-choro-2-fluoro-5-(trifluoromethyl)-pyridine is an organic compound with the formula C6H2ClF4N and a molecular weight of 183.53.
The following is about the properties of 3-choro-2-fluoro-5-(trifluoromethyl)-pyridine:
1. Appearance: colorless to yellowish liquid or solid;
2. melting point:-3 ℃;
3. boiling point: 105 ℃(120 Pa);
4. Relative density: 1.69(20/4 ℃);
5. Refractive index: 1.4075(20 ℃);
6. Solubility: Soluble in many organic solvents, such as ethanol, ether and dichloromethane.
3-chloro-2-fluoro-5-(trifluoromethyl)-The main use of pyridine is as an important intermediate in organic synthesis. It can be used to synthesize organic compounds with biological activity, such as pesticides, pharmaceuticals and preservatives for agricultural products.
The method for preparing 3-chloro-2-fluoro-5-(trifluoromethyl)-pyridine is usually achieved by fluorination of pyridine. Specifically, 2-fluoro-5-chloropyridine can be reacted with a reagent such as trifluoromethylmagnesium bromide or trifluoromethylboron fluoride under appropriate conditions to give the target product.
Regarding the safety information of 3-chloro-2-fluoro-5-(trifluoromethyl)-pyridine, it is an organic compound with certain toxicity and corrosiveness. Therefore, in the use of the need to pay attention to the following matters:
1. Avoid contact with skin, eyes and respiratory tract. Wear protective gloves, goggles, masks and other personal protective equipment during use;
2. Operate in a well-ventilated place to avoid inhaling harmful gases;
3. Store away from fire and oxidant;
4. if accidental contact or inhalation, immediately rinse the affected area with plenty of water and seek medical help;
5. When disposing of waste, it is necessary to properly dispose of it in accordance with local environmental regulations.
The following is about the properties of 3-choro-2-fluoro-5-(trifluoromethyl)-pyridine:
1. Appearance: colorless to yellowish liquid or solid;
2. melting point:-3 ℃;
3. boiling point: 105 ℃(120 Pa);
4. Relative density: 1.69(20/4 ℃);
5. Refractive index: 1.4075(20 ℃);
6. Solubility: Soluble in many organic solvents, such as ethanol, ether and dichloromethane.
3-chloro-2-fluoro-5-(trifluoromethyl)-The main use of pyridine is as an important intermediate in organic synthesis. It can be used to synthesize organic compounds with biological activity, such as pesticides, pharmaceuticals and preservatives for agricultural products.
The method for preparing 3-chloro-2-fluoro-5-(trifluoromethyl)-pyridine is usually achieved by fluorination of pyridine. Specifically, 2-fluoro-5-chloropyridine can be reacted with a reagent such as trifluoromethylmagnesium bromide or trifluoromethylboron fluoride under appropriate conditions to give the target product.
Regarding the safety information of 3-chloro-2-fluoro-5-(trifluoromethyl)-pyridine, it is an organic compound with certain toxicity and corrosiveness. Therefore, in the use of the need to pay attention to the following matters:
1. Avoid contact with skin, eyes and respiratory tract. Wear protective gloves, goggles, masks and other personal protective equipment during use;
2. Operate in a well-ventilated place to avoid inhaling harmful gases;
3. Store away from fire and oxidant;
4. if accidental contact or inhalation, immediately rinse the affected area with plenty of water and seek medical help;
5. When disposing of waste, it is necessary to properly dispose of it in accordance with local environmental regulations.
Last Update：2024-04-09 21:54:55
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