3-Chloro-4-(trifluoromethoxy)aniline
3-Chloro-4-(trifluoromethoxy)aniline
CAS: 64628-73-5
Molecular Formula: C7H5ClF3NO
3-Chloro-4-(trifluoromethoxy)aniline - Names and Identifiers
3-Chloro-4-(trifluoromethoxy)aniline - Physico-chemical Properties
| Molecular Formula | C7H5ClF3NO |
| Molar Mass | 211.57 |
| Density | 1,454 g/cm3 |
| Melting Point | 29-30°C |
| Boling Point | 224℃ |
| Flash Point | 90℃ |
| Water Solubility | Slightly soluble in water. |
| Specific Gravity | 1.454 |
| BRN | 6314199 |
| pKa | 2.68±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
3-Chloro-4-(trifluoromethoxy)aniline - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R43 - May cause sensitization by skin contact R36 - Irritating to the eyes R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36/37 - Wear suitable protective clothing and gloves. |
| HS Code | 29222990 |
| Hazard Note | Toxic/Irritant |
| Hazard Class | IRRITANT, TOXIC |
3-Chloro-4-(trifluoromethoxy)aniline - Introduction
3-Chloro-4-(trifluoromethoxy)aniline is an organic compound with the formula C7H5ClF3NO. It is a yellow to orange-yellow crystalline solid.
Nature:
-Appearance: Yellow to orange-yellow crystalline solid
-Melting point: about 66-69°C
-Boiling point: about 234°C
-relative density: about 1.53g/cm³
-Stability: stable at room temperature, but will be decomposed by light
Use:
3-Chloro-4-(trifluoromethoxy)aniline is widely used as an intermediate in organic synthesis. It can be used to prepare chemicals such as pesticides, pharmaceuticals and dyes.
Preparation Method:
3-Chloro-4-(trifluoromethoxy)aniline can be prepared by reacting p-chloroaniline with trifluoromethanol. The specific preparation steps may be: firstly, p-chloroaniline is added to the reaction vessel, and a reaction solvent is added; then, trifluoromethanol is slowly added dropwise; and finally, a heating reaction is performed, usually under the protection of an inert gas, to obtain the target product.
Safety Information:
3-Chloro-4-(trifluoromethoxy)aniline is a hazardous chemical and should be used in accordance with laboratory safety procedures. Exposure or inhalation of it may cause irritant reactions such as eye and skin irritation. Wear appropriate personal protective equipment such as laboratory gloves, goggles and protective clothing during use. Avoid swallowing and prolonged exposure. If contact occurs, rinse immediately with plenty of water and seek medical help.
Nature:
-Appearance: Yellow to orange-yellow crystalline solid
-Melting point: about 66-69°C
-Boiling point: about 234°C
-relative density: about 1.53g/cm³
-Stability: stable at room temperature, but will be decomposed by light
Use:
3-Chloro-4-(trifluoromethoxy)aniline is widely used as an intermediate in organic synthesis. It can be used to prepare chemicals such as pesticides, pharmaceuticals and dyes.
Preparation Method:
3-Chloro-4-(trifluoromethoxy)aniline can be prepared by reacting p-chloroaniline with trifluoromethanol. The specific preparation steps may be: firstly, p-chloroaniline is added to the reaction vessel, and a reaction solvent is added; then, trifluoromethanol is slowly added dropwise; and finally, a heating reaction is performed, usually under the protection of an inert gas, to obtain the target product.
Safety Information:
3-Chloro-4-(trifluoromethoxy)aniline is a hazardous chemical and should be used in accordance with laboratory safety procedures. Exposure or inhalation of it may cause irritant reactions such as eye and skin irritation. Wear appropriate personal protective equipment such as laboratory gloves, goggles and protective clothing during use. Avoid swallowing and prolonged exposure. If contact occurs, rinse immediately with plenty of water and seek medical help.
Last Update：2024-04-09 15:17:59
