3-Chloro-5-isoquinolinamine

3-Chloro-5-isoquinolinamine - Names and Identifiers

Name	5-Amino-3-chloroisoquinoline
Synonyms	3-Chloro-5-isoquinolinamine 3-CHLOROISOQUINOLIN-5-AMINE 3-Chloro-5-aminoisoquinoline 5-Amino-3-chloroisoquinoline 5-Isoquinolinamine, 3-chloro- 5-Isoquinolinamine,3-chloro-(9CI) 5-Amino-3-chloroisoquinoline hydrochloride
CAS	58142-49-7

3-Chloro-5-isoquinolinamine - Physico-chemical Properties

Molecular Formula	C9H7ClN2
Molar Mass	178.62
Density	1.363±0.06 g/cm3(Predicted)
Boling Point	372.6±27.0 °C(Predicted)
pKa	2.14±0.43(Predicted)
Storage Condition	2-8°C(protect from light)

3-Chloro-5-isoquinolinamine - Introduction

It is an organic compound with the formula C9H7ClN2. The following is a description of its nature, use, preparation and safety information:

Nature:
1. Appearance: White to yellow crystalline solid.
2. Solubility: It dissolves in some organic solvents (such as chloroform, dimethylformamide), but its solubility in water is limited.
3. Melting point: The melting point of is about 130-135 degrees Celsius.

Use:
It is commonly used in organic synthesis and can be used as an intermediate or raw material to participate in the synthesis of different chemical reactions.

Preparation Method:
is generally synthesized by synthetic route, the specific steps are as follows:
1. reaction 1: benzoic acid is reacted with chloroacetyl chloride to form phenylacetyl chloride under the catalysis of base.
2. Reaction 2: Phenylacetyl chloride reacts with phenol to generate benzyl phenylacetate.
3. Reaction 3: Benzyl phenylacetate is reacted with sulfuric acid to generate benzyl ester sulfate.
4. Reaction 4: Benzyl ester sulfate is reacted with ethanol to generate ethyl phenyl acetate.
5. Reaction 5: The reaction of ethyl phenyl acetate with aminoisoquinoline to generate the phenol.

Safety Information:
1. Be careful to prevent contact with skin, eyes and respiratory tract during use and storage.
2. avoid inhalation or intake, avoid prolonged contact. Personal protective equipment such as gloves, safety glasses and protective masks should be worn when necessary.
3. such as accidental contact, should immediately rinse the skin or eyes with plenty of water, if not adapt to consult a doctor as soon as possible.
4. should be stored in a sealed, dry, cool place, away from fire and flammable materials.

Last Update：2024-04-10 22:29:15