3-Fluoro-2-trifluoromethyl-phenylamine
2-Amino-6-Fluorobenzotrifluoride
CAS: 123973-22-8
Molecular Formula: C7H5F4N
3-Fluoro-2-trifluoromethyl-phenylamine - Names and Identifiers
3-Fluoro-2-trifluoromethyl-phenylamine - Physico-chemical Properties
| Molecular Formula | C7H5F4N |
| Molar Mass | 179.11 |
| Density | 1.383g/ml |
| Boling Point | 199.2±35.0 °C(Predicted) |
| Flash Point | 89°C |
| Vapor Presure | 0.345mmHg at 25°C |
| pKa | 0.45±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Refractive Index | 1.4695 |
3-Fluoro-2-trifluoromethyl-phenylamine - Risk and Safety
| Hazard Class | 6.1 |
3-Fluoro-2-trifluoromethyl-phenylamine - Introduction
Amino-6-fluorobenzotrifluoride, also known as 2-fluorobenzotrifluoride, has the following properties:
Nature:
1. Appearance: white solid.
2. solubility: slightly soluble in water, in organic solvents (such as alcohol, ether and ester solvents) more easily dissolved.
3. melting point: about 180-182 degrees Celsius.
Use:
1. Targeted drug research: 2-amino -6-fluorobenzotrifluoride is often used as a synthetic intermediate of heterocyclic compounds to prepare new active compounds for targeted drug research.
2. Synthesis of pesticide heterocyclic compounds: It can also be used for the synthesis of pesticide heterocyclic compounds.
Preparation Method:
There are many methods for preparing 2-amino-6-fluorobenzotrifluoride. One common method is to synthesize it through aromatic nitration reaction and reduction reaction. The specific steps can be briefly described as follows:
1. first 2-amino -6-fluorobenzene and bromination. This can be achieved by dissolving 2-amino-6-fluorobenzoic acid in an alcohol and adding a brominating agent.
2. Next, the obtained 2-amino-6-fluorobenzobromide is reacted with a nitroso group-containing compound to perform a nitrosylation reaction.
3. Finally, by adding sodium hydroxide or sulfoxide salts, a reduction reaction is carried out to obtain 2-amino-6-fluorobenzotrifluoride.
Safety Information:
For specific safety information on 2-amino-6-fluorobenzotrifluoride, please refer to the SDS (Safety Data Sheet) of its related materials and follow laboratory safety operations and measures.
Nature:
1. Appearance: white solid.
2. solubility: slightly soluble in water, in organic solvents (such as alcohol, ether and ester solvents) more easily dissolved.
3. melting point: about 180-182 degrees Celsius.
Use:
1. Targeted drug research: 2-amino -6-fluorobenzotrifluoride is often used as a synthetic intermediate of heterocyclic compounds to prepare new active compounds for targeted drug research.
2. Synthesis of pesticide heterocyclic compounds: It can also be used for the synthesis of pesticide heterocyclic compounds.
Preparation Method:
There are many methods for preparing 2-amino-6-fluorobenzotrifluoride. One common method is to synthesize it through aromatic nitration reaction and reduction reaction. The specific steps can be briefly described as follows:
1. first 2-amino -6-fluorobenzene and bromination. This can be achieved by dissolving 2-amino-6-fluorobenzoic acid in an alcohol and adding a brominating agent.
2. Next, the obtained 2-amino-6-fluorobenzobromide is reacted with a nitroso group-containing compound to perform a nitrosylation reaction.
3. Finally, by adding sodium hydroxide or sulfoxide salts, a reduction reaction is carried out to obtain 2-amino-6-fluorobenzotrifluoride.
Safety Information:
For specific safety information on 2-amino-6-fluorobenzotrifluoride, please refer to the SDS (Safety Data Sheet) of its related materials and follow laboratory safety operations and measures.
Last Update：2024-04-09 21:54:55
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