3-Fluoro-4-(trifluoromethyl)pyridine

3-Fluoro-4-(trifluoromethyl)pyridine - Names and Identifiers

Name	3-Fluoro-4-(trifluoromethyl)pyridine
Synonyms	à,à,à,3-tetrafluoropicoline 3-FLUORO-4-(TRIFLUOROMETHYL)PYRIDINE 3-Fluoro-4-(trifluoromethyl)pyridine Pyridine, 3-fluoro-4-(trifluoromethyl)- alpha,alpha,alpha,3-Tetrafluoropicoline
CAS	113770-87-9
EINECS	623-102-2
InChI	InChI=1/C6H3F4N/c7-5-3-11-2-1-4(5)6(8,9)10/h1-3H

3-Fluoro-4-(trifluoromethyl)pyridine - Physico-chemical Properties

Molecular Formula	C6H3F4N
Molar Mass	165.09
Density	1.391 g/mL at 25 °C
Boling Point	37 °C/10 mmHg
Flash Point	68°F
Vapor Presure	8.101mmHg at 25°C
pKa	0.45±0.18(Predicted)
Storage Condition	Inert atmosphere,Room Temperature
Refractive Index	n20/D 1.406
MDL	MFCD03789250

3-Fluoro-4-(trifluoromethyl)pyridine - Risk and Safety

Risk Codes	R11 - Highly Flammable R25 - Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 1992 3/PG 2
WGK Germany	3
Hazard Note	Flammable
Hazard Class	3
Packing Group	III

3-Fluoro-4-(trifluoromethyl)pyridine - Introduction

3-Fluoro-4-(trifluoromethyl) pyridine, also known as FPyF, is an organic compound. The following is a description of its nature, use, preparation and safety information:

Nature:
The molecular formula of 3-fluoro-4-(trifluoromethyl) pyridine is C6F4N, and the appearance is colorless or white solid. It has a relatively low melting and boiling point and is soluble in polar organic solvents such as acetonitrile, methylene chloride and xylene. Its chemical structure is stable and it is not easy to decompose or be affected by light and heat.

Use:
3-Fluoro-4-(trifluoromethyl) pyridine is an important intermediate in organic synthesis. It is often used as a catalyst for the synthesis of aromatic compounds, the preparation of catalysts and other organic synthesis reactions in organic synthesis reactions. In addition, it is also used to prepare additives for coatings, plastics, rubber and other materials.

Method:
A commonly used synthesis method is to obtain 3-fluoro-4-(trifluoromethyl) pyridine by reacting trichloromethyl pyridine with copper fluoride. The reaction conditions generally require heating, using an organic solvent such as toluene or thionyl chloride as the reaction medium.

Safety Information:
Regarding the safety of 3-fluoro-4-(trifluoromethyl) pyridine, the following matters need to be paid attention:
1. In the operation should follow good laboratory safety procedures, wear appropriate personal protective equipment, such as gloves, safety glasses and laboratory coat.
2. Because it is an organic compound with certain toxicity, direct contact with skin and inhalation of its vapor should be avoided, and ventilation equipment should be used if necessary.
3. during use or storage, avoid contact with chemicals such as oxidants, strong acids or strong bases to avoid adverse reactions.
4. When disposing of waste, it should be properly disposed in accordance with local regulations and should not be dumped or discharged into the environment.

Last Update：2024-04-10 22:29:15