3-Hydroxy-9,10-dimethoxyptercarpan;Medicarpin

Name	3-Hydroxy-9,10-dimethoxyptercarpan Medicarpin
Synonyms	Medicarpi Medicarpin Methylnissolin Astrapterocarpan 3-Hydroxy-9,10-dimethoxyptercarpan L-3-Hydroxy-9,10-dimethoxylpterocarpan 3-Hydroxy-9,10-dimethoxyptercarpanMedicarpin 3-Hydroxy-9,10-dimethoxyptercarpan,Medicarpin,Methylnissolin (-)-6aR,11aR-dihydro-3-hydroxy-9,10-dimethoxy-6H-benzofuro[3,2-c][1]-benzopyran
CAS	73340-41-7

Molecular Formula	C17H16O5
Molar Mass	300.31
Density	1.312
Melting Point	131-132°C
Boling Point	428.9±45.0 °C(Predicted)
Solubility	Almost insoluble in water, cold ethanol or ethyl ether, soluble in hot ethanol and chloroform.
Appearance	White needle crystal powder
pKa	9.44±0.20(Predicted)
Storage Condition	2-8℃
Physical and Chemical Properties	White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Astragalus Astragalus membranaceus (Fisch.) Bunge..

Plant Source:	radix astragali
biological activity	Methylnissolin (AstraZeneca) was isolated from Astragalus membranaceus, inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC50 of 10 μm. Methylnissolin inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (Eric 1/2) mitogen-activated protein (MAP) kinases. Methylnissolin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibiting the ERK1/2 MAP kinase cascade.
Use	antibacterial, anticancer. for content determination/identification/pharmacological experiments, etc

Last Update：2024-04-09 21:01:54