Name | 3-Iodo-L-tyrosine |
Synonyms | H-3-I-Tyr-Oh 3-I-L-Tyr-OH Iodotyrosine H-Tyr(3-I)-Oh H-Tyr(M-I)-Oh H-3-Iodo-Tyr-Oh H-L-Tyr(3-I)-Oh 3-Iodo-Tyrosine 3-Iodo-D-Tyrosine 3-Iodo-L-tyrosine H-3-I-Phe(4-Oh)-Oh L-TYROSINE, 3-IODO- L-Tyrosine, 3-Iodo- Tyrosine,3-Iodo-, L- H-L-Phe(3-I,4-OH)-OH 3-Monoiodo-L-Tyrosine 4-Hydroxy-3-iodophenylalanine 3-Iodo-4-hydroxyphenylalanine (2S)-2-ammonio-3-(4-hydroxy-3-iodophenyl)propanoate (S)-2-AMino-3-(4-hydroxy-3-iodophenyl)propanoic acid |
CAS | 70-78-0 |
EINECS | 200-744-8 |
InChI | InChI=1/C9H10INO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m1/s1 |
InChIKey | UQTZMGFTRHFAAM-ZETCQYMHSA-N |
Molecular Formula | C9H10INO3 |
Molar Mass | 307.09 |
Density | 1.7280 (estimate) |
Melting Point | 210°C (dec.)(lit.) |
Boling Point | 391.0±42.0 °C(Predicted) |
Flash Point | 190.3°C |
Solubility | dilute aqueous acid: soluble |
Vapor Presure | 8.18E-07mmHg at 25°C |
Appearance | White solid |
Color | White to off-white |
Merck | 14,5047 |
BRN | 2941266 |
pKa | 2.21±0.20(Predicted) |
Storage Condition | -20°C |
Stability | Hygroscopic |
Sensitive | Light Sensitive |
Refractive Index | 1.688 |
MDL | MFCD00002608 |
Physical and Chemical Properties | Melting Point 210°C (dec.)(lit.) Storage Conditions 2-8°C solubility dilute aquatic acid: soluble Merck 5047 |
Use | Tyrosine hydroxylase inhibitors. |
In vitro study | H-Tyr(3-I)-OH (3-iodo-L-tyrosine) is as effective inhibitor of tyrosine hydroxylase. At a concentration of 100μM 3-iodo-L-tyrosine inhibits the enzymatic activity 100% and at a concentration of 10μM it inhibits 60-70%. |
Safety Description | 24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
FLUKA BRAND F CODES | 8-10-23 |
HS Code | 29225090 |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
biological activity | H-Tyr(3-I)-OH (3-Iodo-L-tyrosine) is responsible for catalyzing the first step in the norepinephrine biosynthetic pathway. H-Tyr(3-I)-OH is a potent tyrosinase inhibitor. |