3-Methyl-1H-indole-2-carbonitrile

3-Methyl-1H-indole-2-carbonitrile - Names and Identifiers

Name	1H-Indole-2-carbonitrile,3-methyl-
Synonyms	2-Cyano-3-methylindole 3-Methylindole-2-carbonitrile 3-Methyl-1H-indole-2-carbonitrile 1H-Indole-2-carbonitrile,3-methyl- 1H-Indole-2-carbonitrile,3-methyl-(9CI)
CAS	13006-59-2
EINECS	200-589-5

3-Methyl-1H-indole-2-carbonitrile - Physico-chemical Properties

Molecular Formula	C10H8N2
Molar Mass	156.18
Density	1.20
Melting Point	103-104℃
Boling Point	355℃
Flash Point	123℃
pKa	14.21±0.30(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C

3-Methyl-1H-indole-2-carbonitrile - Introduction

2-Cyano-3-methylindole, also known as DMI (methyl pyrazinone), is an organic compound. The following is an introduction to the nature, use, preparation and safety information of 2-cyano-3-methylindole:

Nature:
-Appearance: 2-cyano-3-methylindole is a light yellow to light brown solid.
-Solubility: Soluble in some organic solvents, such as alcohols and ketones, but almost insoluble in water.
-Melting point: about 80-90°C.
-Molecular formula: C10H8N2.

Use:
- 2-cyano-3-methylindole is an important organic synthesis intermediate, often used in the preparation of other compounds. It can participate in many reactions, for example as a nucleophile in organic synthesis, as a reagent for amphiphilic synthesis and cyclization reactions.
- DMI is also used as a fungicide and herbicide. It is commonly used in agriculture and horticulture to control the growth of weeds and pathogens.

Preparation Method:
-The preparation method of 2-cyano-3-methylindole is more complicated and usually requires more steps. A common method of preparation is the reaction of methylpyrazinone with sodium cyanide followed by acidification using concentrated hydrochloric acid.

Safety Information:
-2-cyano-3-methylindole may be harmful to the human body and the environment, so it is necessary to comply with relevant safety procedures when using it.
-It may be irritating to the eyes and skin, and may have toxic effects on the central nervous system.
-Wear appropriate personal protective equipment such as chemical gloves and goggles during operation.
-During storage and handling, avoid contact with strong oxidants to avoid dangerous reactions.
-If you accidentally expose or swallow the compound, you should seek medical attention immediately and provide relevant information to your doctor.

Last Update：2024-04-10 22:29:15