3-N-叔丁氧羰基氨基环己酮
3-N-Boc-aminocyclohexanone
CAS: 885280-38-6
Molecular Formula: C11H19NO3
3-N-叔丁氧羰基氨基环己酮 - Names and Identifiers
3-N-叔丁氧羰基氨基环己酮 - Physico-chemical Properties
| Molecular Formula | C11H19NO3 |
| Molar Mass | 213.27 |
| Density | 1.06±0.1 g/cm3(Predicted) |
| Melting Point | 81-85oC |
| Boling Point | 335.9±31.0 °C(Predicted) |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | Pale Beige |
| pKa | 12.01±0.20(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
3-N-叔丁氧羰基氨基环己酮 - Reference Information
| Use | N-BOC-3-cyclohexanone amine is an organic intermediate, and it has been reported in the literature that it can be used to prepare BTK inhibitors. |
| Preparation | A solution of 2-cyclohexene-1-one (14 ml, 150 mmol) and tert-butyl carbamate (17g, 145.11 mmol) in DCM(30 ml) with bismuth nitrate pentahydrate (14g, 28.8 mmol) Stir at room temperature for 21 hours. Further diluted with DCM, filtered with hyflo, washed the filtrate with sodium bicarbonate solution and brine, dried the organic phase with Na2SO4, filtered and evaporated the solvent to obtain 22.1g of crude product. Silica gel chromatography (EtOAc/cyclohexanol 3:7), followed by crystallization from the same solvent system, obtained N-BOC-3-cyclohexanone amine (14.43g,47%). |
Last Update：2024-04-09 20:52:54
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View History
3-N-叔丁氧羰基氨基环己酮
1-Butene, 1-chloro-, (E)- (8CI,9CI)
(2,2'-联吡啶)二溴化镍(II)
2-氟苄肼盐酸盐
二甲基二苯基醚
4-HYDROXYPROPYLAMINO-3-NITROPHENOL
5-Hydroxy-7-methoxyflavanone
N-[4-[2-(2-胺基-4,7-二氢-4-氧-1H吡咯[2,3-D]嘧啶-5基)乙基]苯甲酰]-L-谷氨酸
2-(对甲苯基)苯甲酸甲酯
ALPHA-PHENYLRESACETOPHENONE
1-Butene, 1-chloro-, (E)- (8CI,9CI)
(2,2'-联吡啶)二溴化镍(II)
2-氟苄肼盐酸盐
二甲基二苯基醚
4-HYDROXYPROPYLAMINO-3-NITROPHENOL
5-Hydroxy-7-methoxyflavanone
N-[4-[2-(2-胺基-4,7-二氢-4-氧-1H吡咯[2,3-D]嘧啶-5基)乙基]苯甲酰]-L-谷氨酸
2-(对甲苯基)苯甲酸甲酯
ALPHA-PHENYLRESACETOPHENONE