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3-amino-4-methoxy-N-phenylbenzamide

3-Amino-p-anisanilide

CAS: 120-35-4

Molecular Formula: C14H14N2O2

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3-amino-4-methoxy-N-phenylbenzamide - Names and Identifiers

Name 3-Amino-p-anisanilide
Synonyms DB-40
Red base KD
Fast Red Base KD
Fast Red Kd Base
3-Amino-p-anisanilide
3-Amino-4-methoxybenzanilide
3-Amino-4-Methoxy-Benzanilide
3-amino-4-methoxy-N-phenylbenzamide
CAS 120-35-4
EINECS 204-388-4
InChI InChI=1/C14H14N2O2/c1-18-13-8-7-10(9-12(13)15)14(17)16-11-5-3-2-4-6-11/h2-9H,15H2,1H3,(H,16,17)

3-amino-4-methoxy-N-phenylbenzamide - Physico-chemical Properties

Molecular FormulaC14H14N2O2
Molar Mass242.28
Density1.245g/cm3
Melting Point154-156°C
Boling Point364.5°C at 760 mmHg
Flash Point174.3°C
Vapor Presure1.67E-05mmHg at 25°C
AppearanceForm Solid, color White to Off-White
pKa13.44±0.70(Predicted)
Storage ConditionKeep in dark place,Inert atmosphere,Room temperature
Refractive Index1.658
MDLMFCD00017166
Physical and Chemical PropertiesChemical white (or light yellow) powder. Melting point 154-155 ℃.
UseUsed as an intermediate in organic synthesis

3-amino-4-methoxy-N-phenylbenzamide - Risk and Safety

Risk Codes36/37/38 - Irritating to eyes, respiratory system and skin.
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
RTECSCV7400000
TSCAYes
Hazard ClassIRRITANT

3-amino-4-methoxy-N-phenylbenzamide - Upstream Downstream Industry

Raw MaterialsSulfuric acid
Potassium permanganate
Dichloroethane
Sodium hydrosulfide
p-Anisic acid
4-Chlorobenzoic acid
Downstream ProductsPigment Red 32
Pigment Red 146
Pigment Red 31
Pigment Red 176

3-amino-4-methoxy-N-phenylbenzamide - Nature

Solubility DMSO (Slightly), Methanol (Slightly)
EPA chemical information Benzamide, 3-amino-4-methoxy-N-phenyl- (120-35-4)
Last Update：2024-04-10 22:29:15

3-amino-4-methoxy-N-phenylbenzamide - Uses and synthesis methods

Production method

method 1 is a commonly used method in current production. Using o-nitroanisole as raw material, the product is obtained by chloromethylation, hydrolysis, oxidation, acyl chlorination, condensation, and reduction..

This method has long process route, long production cycle and low product yield.

method 2 is the latest research method. Using p-chlorobenzoic acid as raw material, the product is obtained by methoxylation, nitration, condensation and reduction. This method has a short process route, high product yield and low cost..

adding 46.8g p-chlorobenzoic acid, 250mL methanol and 12g auxiliary TR-300 into the reactor, refluxing for 10h to obtain 41.5g p-methoxybenzoic acid. Add it into a nitrocer, add 166g of dichloroethane and 0.5g of sulfuric acid (98%) at the same time, add 19g of nitric acid (98%) dropwise at 45 ℃, add it within 3h, continue the heat preservation reaction for 2h, and obtain 52.7g of nitrification product. Add it into the condensate, add 200mL of solvent and 40mL of aniline at the same time, raise the temperature to (98±2)℃, add 30mL of thionyl chloride dropwise (added within 30min), continue the heat preservation reaction for 4h, and obtain 70.0g of condensation product. Add it into the reducer, add 350mL sodium hydrosulfide solution (30%) at the same time, raise the temperature to (80±2)℃ for 15h, and obtain 51.8g of the final product.

category

Toxic substances

Toxicity classification

Poisoning

Acute toxicity

intravenous-mouse LD50: 320 mg/kg

flammability hazard characteristics

Combustible; combustion produces toxic nitrogen oxide smoke

storage and transportation features

Warehouse ventilation low temperature drying

Fire extinguishing agent

Dry powder, foam, sand, carbon dioxide, mist water

Last Update：2024-04-09 21:01:54
3-amino-4-methoxy-N-phenylbenzamide
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Jiangsu Pules Biotechnology Co.,Ltd.
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CAS: 120-35-4
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CAS: 120-35-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: 3-Amino-p-anisanilide Request for quotation
CAS: 120-35-4
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: 3-Amino-p-anisanilide Request for quotation
CAS: 120-35-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple Specifications
Product Name: 3-Amino-4-methoxybenzanilide Visit Supplier Webpage Request for quotation
CAS: 120-35-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
View History
3-amino-4-methoxy-N-phenylbenzamide
Raw Materials for 3-amino-4-methoxy-N-phenylbenzamide
Sulfuric acid
Potassium permanganate
Dichloroethane
Sodium hydrosulfide
p-Anisic acid
4-Chlorobenzoic acid
Downstream Products for 3-amino-4-methoxy-N-phenylbenzamide
Pigment Red 32
Pigment Red 146
Pigment Red 31
Pigment Red 176
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