3-broMo-5,6-diMethylpyridine

3-broMo-5,6-diMethylpyridine - Names and Identifiers

Name	2,3-Dimethyl-5-bromopyridine
Synonyms	3-DIMETHYLPYRIDINE 5-Bromo-2,3-lutidine 5-Bromo-2,3-dimethylpyridine 5-BROMO-2,3-DIMETHYLPYRIDINE 2,3-Dimethyl-5-bromopyridine 2,3-DiMethyl-5-broMopyridine 3-broMo-5,6-diMethylpyridine Pyridine, 5-bromo-2,3-dimethyl-
CAS	27063-90-7

3-broMo-5,6-diMethylpyridine - Physico-chemical Properties

Molecular Formula	C7H8BrN
Molar Mass	186.05
Density	1.415±0.06 g/cm3(Predicted)
Boling Point	40℃ (40 Torr)
pKa	3.89±0.20(Predicted)
Storage Condition	Inert atmosphere,Room Temperature
Sensitive	Irritant
MDL	MFCD11656270

3-broMo-5,6-diMethylpyridine - Reference Information

Use

2,3-dimethyl-5-bromopyridine is an organic intermediate that can be obtained by preparing 2, 3-dimethylpyridine in one step. It can be used as a pharmaceutical intermediate.

Preparation

Bromine (0.3mL) was added dropwise to a solution of 2,3-dimethylpyridine (0.51mL) in fuming sulfuric acid (10mL) at 155°C for 2 hours. The reaction mixture was then heated at 155°C for 16 hours. After cooling to room temperature, pour the mixture on ice and adjust the ph to 10 with an aqueous sodium hydroxide solution. The product was extracted into ethyl acetate (3 × 40mL), and the organic layer was dried (MgSO4), concentrated under reduced pressure and purified on silica to give a yellow oily 2, 3-dimethyl-5-bromopyridine.

Last Update：2024-04-09 15:16:35