3-bromo-5-(trifluoromethyl)pyridine-2-amine

3-bromo-5-(trifluoromethyl)pyridine-2-amine - Names and Identifiers

Name	2-Amino-3-bromo-5-(trifluoromethyl)pyridine
Synonyms	2-Amino-3-bromo-5-(trifL 2-Amino-3-bromo-5-(trifluorome 3-bromo-5-(trifluoromethyl)pyridin-2-amine 3-Bromo-5-(trifluoromethyl)pyridin-2-amine 3-bromo-5-(trifluoromethyl)pyridine-2-amine 3-Bromo-5-trifluoromethyl-pyridin-2-ylamine 2-Amino-3-bromo-5-(trifluoromethyl)pyridine 2-Amino-3-bromo-5-(trifluoromethyl)-pyridine 2-pyridinamine, 3-bromo-5-(trifluoromethyl)- 2-Amino-3-Bromo-5-(Trifluoromethyl)-Pyridine 3-Bromo-5-(trifluoromethyl)pyridin-2-amine, 6-Amino-5-bromo-alpha,alpha,alpha-trifluoro-3-picoline
CAS	79456-30-7
InChI	InChI=1/C6H4BrF3N2/c7-4-1-3(6(8,9)10)2-12-5(4)11/h1-2H,(H2,11,12)

3-bromo-5-(trifluoromethyl)pyridine-2-amine - Physico-chemical Properties

Molecular Formula	C6H4BrF3N2
Molar Mass	241.01
Density	1.790±0.06 g/cm3(Predicted)
Melting Point	98-101℃
Boling Point	221.7±40.0 °C(Predicted)
Flash Point	87.883°C
Vapor Presure	0.106mmHg at 25°C
Appearance	Solid
pKa	1.79±0.49(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature
Refractive Index	1.525
MDL	MFCD07375382

3-bromo-5-(trifluoromethyl)pyridine-2-amine - Risk and Safety

Hazard Class

IRRITANT

3-bromo-5-(trifluoromethyl)pyridine-2-amine - Introduction

2-Amino-3-brom-5-(trifluoromethyl)pyridine is an organic compound with the chemical formula C6H4BrF3N2. Its molecular structure contains a pyridine ring and a bromine atom, as well as an amino group and a trifluoromethyl group.

Its physical properties are as follows:
Appearance: White solid
Melting point: 82-84°C
Boiling point: 238-240°C
Density: 1.86g/cm³
Solubility: Slightly soluble in water, soluble in organic solvents such as ethanol, ether and dichloromethane.

One of the main uses of 2-Amino-3-bromo-5-(trifluoromethyl)pyridine is as a pharmaceutical intermediate. It can be used to prepare biologically active compounds, such as drugs, pesticides and dyes. In addition, it can also be used as a ligand to participate in chemical reactions induced by metal ions, such as metal catalyzed reactions and chemical sensing.

The synthesis method of the compound can be achieved by bromopyridine and amination reaction. The specific steps include reacting the bromopyridine with ammonia, replacing the bromine atom with an amino group under basic conditions, and then introducing a trifluoromethyl group under the action of a trifluoromethylation reagent.

Regarding safety information, 2-Amino-3-bromo-5-(trifluoromethyl)pyridine is an organic compound and should be used with attention to protective measures. It may have irritating and corrosive effects on the eyes, skin and respiratory system. Avoid direct contact during operation and ensure good ventilation conditions. It is recommended to wear personal protective equipment such as protective glasses, gloves and protective masks when using. At the time of disposal, please follow the local chemical waste disposal requirements. During storage, it should be stored in a low temperature, dry and ventilated place, avoiding contact with oxidants and acids.

Last Update：2024-04-09 20:52:54