3-chloro-2-hydroxypyridin-4(1H)-one

3-chloro-2-hydroxypyridin-4(1H)-one - Names and Identifiers

Name	2(1H)-Pyridinone,3-chloro-4-hydroxy-(9CI)
Synonyms	3-Chloro-2,4-dihydroxypyridine 5-Chloro-4-hydroxy pyridinone-2 3-Chloro-4-hydroxy-2(1H)-pyridinone 3-chloro-2-hydroxypyridin-4(1H)-one 3-chloro-2-hydroxy-1H-pyridin-4-one 3-Chloro-4-hydroxypyridin-2(1H)-one 2(1H)-Pyridinone, 3-chloro-4-hydroxy- 2(1H)-Pyridinone,3-chloro-4-hydroxy-(9CI) 3-chloro-4-hydroxy-1,2-dihydropyridin-2-one
CAS	103792-81-0
InChI	InChI=1/C5H4ClNO2/c6-4-3(8)1-2-7-5(4)9/h1-2H,(H2,7,8,9)

3-chloro-2-hydroxypyridin-4(1H)-one - Physico-chemical Properties

Molecular Formula	C5H4ClNO2
Molar Mass	145.54
Density	1.56
Melting Point	310 °C (decomp)
Boling Point	283 ºC
Flash Point	125 ºC
Vapor Presure	0.00412mmHg at 25°C
pKa	4.50±1.00(Predicted)
Storage Condition	Room Temprature
Refractive Index	1.617
MDL	MFCD11101041

3-chloro-2-hydroxypyridin-4(1H)-one - Introduction

3-Chloro-2, 4-dihydroxypyridine is an organic compound with the chemical formula C5H4ClNO2, often abbreviated as 3-Cl-2,4-DHP. The following is an introduction to some of its properties, uses, methods and safety information:

Nature:
1. Appearance: 3-chloro-2, 4-dihydroxypyridine is a colorless to pale yellow crystalline solid.
2. Melting point: Its melting point is about 228-230 degrees Celsius.
3. Solubility: 3-chlorine -2, 4-dihydroxypyridine has low solubility in water, but it can be dissolved in organic solvents such as alcohol, ether, etc.

Use:
1. Pesticide: 3-Chloro-2, 4-dihydroxypyridine is a broad-spectrum pesticide that can be used to control pests on a variety of agricultural crops.
2. Medicine: It is also used as a pharmaceutical intermediate and can be used to synthesize other compounds with medicinal value.

Preparation Method:
3-Chloro-2, 4-dihydroxypyridine is mainly prepared by the following methods:
1. Hydroxylation method: it is obtained by reacting 2,4-dihydroxypyridine with cuprous chloride, and then further hydroxylation with silver chloride.
2. Hydroxychlorination method: it is obtained by reacting 2,4-dihydroxypyridine with cuprous chloride under the catalysis of stannous chloride.
3. hydroxylation-chlorination method: by reacting 2,4-dihydroxypyridine with sodium chlorite to obtain an intermediate product, and then reacting with chlorous acid and sodium chloride for hydroxylation.

Safety Information:
The following points should be noted when using 3-chloro-2, 4-dihydroxypyridine:
1. Avoid direct contact: gloves and protective glasses should be used when handling 3-chloro-2, 4-dihydroxypyridine to avoid skin and eye irritation or damage.
2. storage note: 3-chlorine -2, 4-dihydroxypyridine should be stored in a dry, cool place, away from fire and oxidant, avoid high temperature and direct sunlight.
3. Toxic effects: 3-chloro-2, 4-dihydroxypyridine has certain toxicity, and long-term exposure or exposure may cause health effects. Relevant safety data should be read carefully before use and chemical safety procedures should be strictly followed.

Last Update：2024-04-09 19:05:44