3-fluoro-4-chlorophenol
4-Chloro-3-fluorophenol
CAS: 348-60-7
Molecular Formula: C6H4ClFO
3-fluoro-4-chlorophenol - Names and Identifiers
| Name | 4-Chloro-3-fluorophenol |
| Synonyms | QR DG CF 348-60-7 3-fluoro-4-chlorophenol 4-CHLORO-3-FLUOROPHENOL 4-Chloro-3-fluorophenol Phenol, 4-chloro-3-fluoro- |
| CAS | 348-60-7 |
| EINECS | 609-036-7 |
| InChI | InChI=1/C6H4ClFO/c7-5-2-1-4(9)3-6(5)8/h1-3,9H |
3-fluoro-4-chlorophenol - Physico-chemical Properties
| Molecular Formula | C6H4ClFO |
| Molar Mass | 146.55 |
| Density | 1.3675 (estimate) |
| Melting Point | 54-56 °C (lit.) |
| Boling Point | 84 °C/44 mmHg (lit.) |
| Flash Point | >230°F |
| Solubility | chloroform: soluble50mg/mL, clear, colorless |
| Vapor Presure | 1.59mmHg at 25°C |
| Appearance | Liquid |
| Color | Colorless to pale yellow, may discolor to orange during storage |
| BRN | 3236440 |
| pKa | 8.52±0.18(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.547 |
3-fluoro-4-chlorophenol - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S24/25 - Avoid contact with skin and eyes. |
| UN IDs | 2811 |
| WGK Germany | 3 |
| HS Code | 29081990 |
| Hazard Note | Irritant |
| Hazard Class | 8 |
3-fluoro-4-chlorophenol - Reference Information
| Application | 4-chloro-3-fluorophenol is an organic intermediate that can be prepared from o-fluoronitrobenzene as raw material 4-amino-3-fluorophenol, and then acylation reaction to produce 4-chloro-3-fluorophenol, which can be used in laboratory research and development processes and chemical production processes. |
| preparation | (1) mixing deionized water and anhydrous ethanol, adding concentrated sulfuric acid dropwise, finally adding o-fluoronitrobenzene and catalyst into the reaction kettle, sealing the kettle, introducing hydrogen into the reaction kettle until the pressure of the reaction kettle is 0.1-0.4MPa, then stirring in the 1000 r/min state, and heating to 60 ℃ at the same time, the pressure in the reaction kettle was increased to 0.4-0.6MPa, and the reaction was carried out for 1h. After the reaction, it was cooled to room temperature and filtered. The obtained filtrate was extracted three times with ethyl acetate, and the organic phase obtained by the three times was collected and distilled under reduced pressure to obtain crude product. Then the crude product was recrystallized and dried with petroleum ether to obtain 4-amino -3-fluorophenol; the purity of 4-amino-3-fluorophenol is 95.68%, and the yield is 80.3%; wherein, the catalyst is a porous silicon oxide supported palladium-carbon composite catalyst; in the catalyst, the mass ratio of porous silicon oxide to palladium-carbon is 40:3; The mass ratio of the catalyst to o-fluoronitrobenzene is 1: 10;(2) N,N-dimethylformamide is used as the reaction medium, 4-amino -3 fluorophenol and acid chloride reagent undergo acyl chlorination reaction to produce 4-chloro -3 fluorophenol. |
Last Update：2024-04-09 21:11:58
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View History
3-fluoro-4-chlorophenol
N-BUTYLTRIMETHYLMETHANE
5-PYRIMIDINEMETHANOL,ALPHA-CYCLOPROPYL-ALPHA-(PARA-METHOXYPHENYL)
聚碳酸乙烯酯
溴代乙酸
N-TRIS(HYDROXYMETHYL)METHYL-2-AMINO-ETHANESULFONIC ACID, DISODIUM SALT
Melphalan Impurity B
还原棕5
9-ACETYLCARBAZOLE 97
Ethyl adamantan-1-ylacetate
N-BUTYLTRIMETHYLMETHANE
5-PYRIMIDINEMETHANOL,ALPHA-CYCLOPROPYL-ALPHA-(PARA-METHOXYPHENYL)
聚碳酸乙烯酯
溴代乙酸
N-TRIS(HYDROXYMETHYL)METHYL-2-AMINO-ETHANESULFONIC ACID, DISODIUM SALT
Melphalan Impurity B
还原棕5
9-ACETYLCARBAZOLE 97
Ethyl adamantan-1-ylacetate