3-fluoro-5-trifluoromethylpyridine

3-fluoro-5-trifluoromethylpyridine - Names and Identifiers

Name	3-fluoro-5-trifluoromethylpyridine
Synonyms	3-fluoro-5-trifluoromethylpyridine 3-Fluoro-5-(trifluoroMethyl)picolinic acid 3-Fluoro-5-(trifluoromethyl)-2-pyridinecarboxylic acid 3-Fluoro-5-(trifluoromethyl)pyridine-2-carboxylic acid 2-Pyridinecarboxylic acid, 3-fluoro-5-(trifluoroMethyl)- 2-pyridinecarboxylic acid, 3-fluoro-5-(trifluoromethyl)-
CAS	89402-28-8
EINECS	1312995-182-4
InChI	InChI=1/C7H3F4NO2/c8-4-1-3(7(9,10)11)2-12-5(4)6(13)14/h1-2H,(H,13,14)

3-fluoro-5-trifluoromethylpyridine - Physico-chemical Properties

Molecular Formula	C7H3F4NO2
Molar Mass	209.1
Density	1.573±0.06 g/cm3(Predicted)
Boling Point	244.7±40.0 °C(Predicted)
Flash Point	101.8°C
Vapor Presure	0.016mmHg at 25°C
pKa	2.20±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.457

3-fluoro-5-trifluoromethylpyridine - Risk and Safety

Hazard Symbols	Xi - Irritant
Hazard Class	IRRITANT

3-fluoro-5-trifluoromethylpyridine - Introduction

It is an organic compound with the chemical formula of C6H3F4N. It is a colorless to pale yellow liquid with a strong pungent odor at room temperature.

Regarding its properties, the compound has high thermal and chemical stability. It is not readily volatile under conventional conditions and is soluble in most organic solvents. In addition, it can react with other compounds and participate in various organic synthesis reactions such as nucleophilic substitution and catalytic reactions.

In industry and laboratories, it is widely used as a starting material for organic synthesis. It can be used to synthesize various bioactive molecules, such as drugs, pesticides, dyes and cosmetics. In addition, it can also be used as a catalyst or ligand for the catalyst pathway in organic synthesis reactions.

The method of preparing the salt can take a variety of approaches. A common method is to introduce a trifluoromethyl group and a fluorine atom by a fluoroalkylation reaction using trifluoromethanesulfonyl fluoride (Triflic fluoride) and pyridine.

Regarding safety information, the operator should operate in a well-ventilated area. It is irritating to the eyes, skin, and respiratory tract, and the affected area should be flushed with plenty of water immediately after contact. At the same time, appropriate personal protective measures must be taken, such as wearing protective glasses, gloves and respiratory protective equipment. In addition, this compound is also toxic and should be stored properly and avoid mixing with other chemicals. Always consult the relevant Safety Data Sheet (SDS) before use. The most important thing is that any chemical operation should be carried out under safe conditions and strictly follow the relevant codes of practice and safety guidelines.

Last Update：2024-04-09 21:54:55