3-hydroxy-4-chlorobenzaldehyde

3-hydroxy-4-chlorobenzaldehyde - Names and Identifiers

Name	4-Chloro-3-Hydroxybenzaldehyde
Synonyms	4-Chloro-3-Hydroxybenzaldehyde 3-hydroxy-4-chlorobenzaldehyde Benzaldehyde, 4-chloro-3-hydroxy-
CAS	56962-12-0

3-hydroxy-4-chlorobenzaldehyde - Physico-chemical Properties

Molecular Formula	C7H5ClO2
Molar Mass	156.57
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C

3-hydroxy-4-chlorobenzaldehyde - Reference Information

use

4-chloro-3-hydroxybenzaldehyde can be used as an intermediate in pharmaceutical synthesis.

preparation

4-chloro-3-hydroxybenzaldehyde is prepared as follows: p-toluenesulfonic acid (3.4g,20mmol) is added to acetonitrile (50mL) solution of 3-hydroxybenzaldehyde (1g,10mmol) in batches. The mixture was stirred at room temperature for 5 minutes, NCS(1.33g,10mmol) was added, and the resulting mixture was stirred at room temperature for 2 hours. The mixture was quenched with an aqueous solution of sodium thiosulfate and diluted with ethyl acetate and brine. The organic layer was separated, dried and concentrated to obtain the crude product, which was purified by silica gel chromatography and eluted with petroleum ether/ethyl acetate (10:1 to 5:1) to obtain 4-chloro-3-hydroxybenzaldehyde (310mg,19.7%), which is a yellow solid.

Last Update：2024-04-09 19:05:11