3-iodo-2-aMinopyridine
2-Amino-3-iodopyridine
CAS: 104830-06-0
Molecular Formula: C5H5IN2
3-iodo-2-aMinopyridine - Names and Identifiers
| Name | 2-Amino-3-iodopyridine |
| Synonyms | 3-IODOPYRIDIN-2-AMINE 3-Iodopyrid-2-ylaMine 3-iodopyridin-2-amine 3-iodo-2-aMinopyridine 2-Amino-3-iodopyridine 2-AMINO-3-IODOPYRIDINE 3-IODO-PYRIDIN-2-YLAMINE (2E)-3-(3-Pyridinyl)acrylic acid (2E)-3-(Pyridin-3-yl)acrylic acid 1-(3-iodopyridin-2-yl)methanamine (2E)-3-(pyridin-3-yl)prop-2-enoic acid 2-propenoic acid, 3-(3-pyridinyl)-, (2E)- |
| CAS | 104830-06-0 |
| EINECS | 624-002-1 |
| InChI | InChI=1/C6H7IN2/c7-5-2-1-3-9-6(5)4-8/h1-3H,4,8H2 |
| InChIKey | UUDNBWSHTUFGDQ-UHFFFAOYSA-N |
3-iodo-2-aMinopyridine - Physico-chemical Properties
| Molecular Formula | C5H5IN2 |
| Molar Mass | 220.01 |
| Density | 2.055±0.06 g/cm3(Predicted) |
| Melting Point | 87-91 °C |
| Boling Point | 289.6±25.0 °C(Predicted) |
| Flash Point | 125.3°C |
| Solubility | soluble in Methanol |
| Vapor Presure | 0.00314mmHg at 25°C |
| Appearance | Bright yellow needle |
| Color | White to pale brown |
| pKa | 4.50±0.36(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Sensitive | Air & Light Sensitive |
| Refractive Index | 1.653 |
| MDL | MFCD01651885 |
3-iodo-2-aMinopyridine - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
| WGK Germany | 2 |
| HS Code | 29333990 |
| Hazard Class | IRRITANT |
3-iodo-2-aMinopyridine - Reference Information
| Uses | 2-amino-3-iodopyridine can be used as an organic intermediate, mainly used for structural modification and derivatization of pyridine-containing drug molecules and bioactive molecules. |
| synthesis method | 2-fluoro -3-iodopyridine (1mmol,223.0mg), ethylamide hydrochloride (1.2mmol,113.4mg),NaOH(2.5mmol,100mg),HO(0.5mL) and dimethyl sulfoxide (2.5mL) are added to a 25 ml reaction tube. The reaction was carried out at 130 ℃ for 24 hours. After the reaction was completed, it was cooled to room temperature. Add 10mL of ethyl acetate to quench the reaction, add 6mL of saturated salt water to wash, separate the organic phase, then extract the aqueous phase with ethyl acetate for 3 times (the amount of ethyl acetate each time is 6mL) and combine the organic phase, add anhydrous sodium sulfate to dry, and remove the solvent including organic solvent and inorganic solvent by vacuum distillation. The organic solvent is separated by column chromatography to obtain the target product 2-amino -3-iodopyridine with a yield of 95%. The products were qualitatively analyzed by gas chromatography-mass spectrometry (Gas chromatography-mass spectrometry,GC-MS) and nuclear magnetic resonance spectrometer (nuclear magnetic resonance spectrometer,NMR). Among them, the GC-MS uses an electron impact ionization (EI) source with an ionization voltage of 70eV and measured m/z. 220,127,93,66. H NMR(400MHz,CDCl),δ8.02(dd,J = 4.8,1.5Hz,1H),7.86(dd,J = 7.7,1.6Hz,1H),6.39(dd,J = 7.7,4.9Hz,1H),5.00(s,2H);C NMR(100MHz,CDCl),δ157.5,147.8,147.1,115.3,77.7. |
Last Update：2024-04-09 15:16:46
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