3-morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one

Name	5,6-Dihydro-3-(4-morpholinyl)-1-[4-(2-oxo-1-piperidinyl)phenyl]-2(1H)-pyridinone
Synonyms	HSK00001094 Apixaban Impurity P Apixaban Impurity H Apixaban Intermediates 3-Morpholino-1-(4-(2-oxopiperidin-1-yl) 1-(4-(3-morpholino-2-oxocyclohex-3-enyl)phenyl)piperidin-2-one 3-Morpholino-1-[4-(2-oxo-1-piperidyl)phenyl]-5,6-dihydropyridin-2(1H)-one 3-morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one 5-morpholin-4-yl-1-[4-(2-oxopiperidin-1-yl)phenyl]-2,3-dihydropyridin-6-one 3-Morpholin-4-yl-1-[4-(2-oxopiperidin-1-yl)phenyl]-5,6-dihydro-1H-pyridin-2-one 5,6-Dihydro-3-(4-morpholinyl)-1-[4-(2-oxo-1-piperidinyl)phenyl]-2(1H)-pyridinone
CAS	545445-44-1
EINECS	1308068-626-2

Molecular Formula	C20H25N3O3
Molar Mass	355.43
Density	1.267
Melting Point	>199°C (dec.)
Boling Point	625.0±55.0 °C(Predicted)
Flash Point	331.775 °C
Solubility	Chloroform (Slightly), Methanol (Slightly)
Appearance	Solid
Color	Pale Beige
pKa	3.25±0.20(Predicted)
Storage Condition	2-8°C
Use	This product is for scientific research only and shall not be used for other purposes.

Overview	5, 6-dihydro-3-(4-morpholinyl)-1-[4-(2-oxo-1-piperidinyl) phenyl]-2(1H)-pyridone is one of the apixaban impurities. Apixaban (Apixaban) is an oral selective activation factor X inhibitor, jointly developed by Pfizer and Bristol-Myers Squibb. In January 2013, it obtained the import drug license issued by the State Food and Drug Administration of China, and was officially listed in China in April 2013.
Use	5, 6-dihydro-3-(4-morpholinyl)-1-[4-(2-oxo-1-piperidinyl) phenyl]-2(1H)-pyridone is a useful research chemical. 5, 6-dihydro-3-(4-morpholinyl)-1-[4-(2-oxo-1-piperidinyl) phenyl]-2(1H)-pyridone is an intermediate for the preparation of apixaban.
Preparation method	Literature method Preparation of 1-(4-methoxyphenyl)-6-(4-aminophenyl)-7-oxo -4,5,6, 7-tetrahydro-1H-pyrazole [3,4-c] pyridine -3-ethyl acetate, a large amount of iron mud will be produced by iron powder reduction, the pollution is serious and it is not suitable to enlarge the production.

Last Update：2024-04-09 21:11:58

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Product Name: Apixaban Impurity 26 Visit Supplier Webpage Request for quotation
CAS: 545445-44-1
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

Wechat: 18301782025

Product List: View Catalog

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3-morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one Request for Quotation