3-phenyl-2H-pyrazole-4-carboxaldehyde
5-phenyl-1H-pyrazole-4-carbaldehyde
CAS: 26033-20-5
Molecular Formula: C10H8N2O
3-phenyl-2H-pyrazole-4-carboxaldehyde - Names and Identifiers
3-phenyl-2H-pyrazole-4-carboxaldehyde - Physico-chemical Properties
| Molecular Formula | C10H8N2O |
| Molar Mass | 172.18 |
| Density | 1.1841 (rough estimate) |
| Melting Point | 146-148 °C |
| Boling Point | 302.5°C (rough estimate) |
| Flash Point | 210.3°C |
| Vapor Presure | 2.55E-07mmHg at 25°C |
| Appearance | Powder |
| Color | Light yellow |
| pKa | 11.17±0.50(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.7040 (estimate) |
| MDL | MFCD00216971 |
3-phenyl-2H-pyrazole-4-carboxaldehyde - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed |
| Safety Description | S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| HS Code | 29331990 |
| Hazard Class | IRRITANT |
3-phenyl-2H-pyrazole-4-carboxaldehyde - Introduction
A, also known as A, is an organic compound. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: It is a yellow crystalline solid.
-Solubility: It has good solubility in common organic solvents, such as ethanol, dimethylformamide, etc.
-Melting point: Its melting point is about 100-102°C.
Use:
-is often used as an intermediate in organic synthesis reactions for the synthesis of other organic compounds.
-It has certain application value in the field of medicine, and can be used as a precursor of anti-tumor drugs and anti-inflammatory drugs.
Method:
It is usually synthesized by the following steps:
1. The phenyl carboxylic acid and isonitrimethamide first react to obtain the phenyl carboxylic acid isonitrio ester.
2. The reaction of isonitridephenyl formate and malonic acid dianhydride to obtain 3-phenyl -1H-pyrazole -4-carboxylic acid dimethyl ester.
3. 3-phenyl-1H-pyrazole-4-carboxylic acid dimethyl demethyl Ester is finally converted to pyridine by reduction and condensation reaction.
Safety Information:
-Appropriate laboratory and personal protective measures, such as protective glasses and gloves, should be taken when using the product.
-may cause irritation to the eyes, skin and respiratory tract, so contact should be avoided. In case of accidental contact, flush with water immediately and seek medical help.
-The toxicity and environmental impact of the cyanide are not fully understood, so the relevant safety regulations and environmental regulations should be observed during handling and disposal.
Nature:
-Appearance: It is a yellow crystalline solid.
-Solubility: It has good solubility in common organic solvents, such as ethanol, dimethylformamide, etc.
-Melting point: Its melting point is about 100-102°C.
Use:
-is often used as an intermediate in organic synthesis reactions for the synthesis of other organic compounds.
-It has certain application value in the field of medicine, and can be used as a precursor of anti-tumor drugs and anti-inflammatory drugs.
Method:
It is usually synthesized by the following steps:
1. The phenyl carboxylic acid and isonitrimethamide first react to obtain the phenyl carboxylic acid isonitrio ester.
2. The reaction of isonitridephenyl formate and malonic acid dianhydride to obtain 3-phenyl -1H-pyrazole -4-carboxylic acid dimethyl ester.
3. 3-phenyl-1H-pyrazole-4-carboxylic acid dimethyl demethyl Ester is finally converted to pyridine by reduction and condensation reaction.
Safety Information:
-Appropriate laboratory and personal protective measures, such as protective glasses and gloves, should be taken when using the product.
-may cause irritation to the eyes, skin and respiratory tract, so contact should be avoided. In case of accidental contact, flush with water immediately and seek medical help.
-The toxicity and environmental impact of the cyanide are not fully understood, so the relevant safety regulations and environmental regulations should be observed during handling and disposal.
Last Update：2024-04-09 21:00:56
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Product Name: 3-Phenyl-1H-pyrazole-4-carboxaldehyde Visit Supplier Webpage Request for quotationCAS: 26033-20-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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