3-溴甲基-5-氯-N-Boc-吲唑

3-溴甲基-5-氯-N-Boc-吲唑 - Names and Identifiers

Name	1H-Indazole-1-carboxylic acid, 3-(bromomethyl)-5-chloro-, 1,1-dimethylethyl ester
Synonyms	1-Boc-3-(Bromomethyl)-5-chloro-1H-indazole tert-butyl 3-(bromomethyl)-5-chloroindazole-1-carboxylate tert-Butyl 3-(bromomethyl)-5-chloro-1H-indazole-1-carboxylate 1H-Indazole-1-carboxylic acid, 3-(broMoMethyl)-5-chloro-, 1,1-diMethylethyl ester 1H-Indazole-1-carboxylic acid, 3-(bromomethyl)-5-chloro-, 1,1-dimethylethyl ester
CAS	944899-43-8

3-溴甲基-5-氯-N-Boc-吲唑 - Physico-chemical Properties

Molecular Formula	C13H14BrClN2O2
Molar Mass	345.62
Storage Condition	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

3-溴甲基-5-氯-N-Boc-吲唑 - Introduction

1H-Indazole-1-carboxylic acid, 3-(bromomethyl)-5-chloro-, 1,1-dimethylethyl ester is an organic compound with the chemical formula C14H14BrClN2O2 and a molecular weight of 354.63g/mol. It is a white crystalline solid, soluble in organic solvents such as methylene chloride, acetone and ethyl acetate.

This compound has important applications in the field of pharmaceutical research. It is a precursor compound of indazole derivatives, which can be used to synthesize drugs or bioactive molecules. Indazole compounds have a wide range of applications in the field of medicine, including anti-tumor, anti-infection, immune regulation and so on.

Its preparation method can be obtained by reacting 3-bromomethyl-5-chloro-1H-indazole with a Boc protecting group. First, 3-bromomethyl-5-chloro-1H-indazole is reacted with an appropriate bromoalkane (e. g., methyl bromide) under basic conditions to yield the corresponding bromomethyl compound. The bromomethyl compound is then esterified with the Boc(tert-butoxycarbonyl) protecting group under acidic conditions to give 1H-Indazole-1-carboxylic acid, 3-(bromomethyl)-5-chloro-, 1,1-dimethylethyl ester.

Regarding safety information, due to the lack of specific safety data, it is recommended to follow laboratory specifications and safe operating procedures during operation. Skin contact and inhalation should be avoided due to the risks of the compounds, including irritation and infectivity. Appropriate personal protective equipment, such as lab gloves and goggles, should be worn during use.

Last Update：2024-04-09 21:04:16