301356-95-6
CID5721353
CAS: 301356-95-6
Molecular Formula: C15H9BrN2O6S2
301356-95-6 - Names and Identifiers
301356-95-6 - Physico-chemical Properties
| Molecular Formula | C15H9BrN2O6S2 |
| Molar Mass | 457.28 |
| Density | 2.06±0.1 g/cm3(Predicted) |
| Solubility | DMSO : 83.33 mg/mL (182.23 mM |
| pKa | 3.02±0.23(Predicted) |
| Storage Condition | -20°C |
| In vitro study | The BCL6 inhibitor 79-6 has cell permeability and can selectively inhibit the transcriptional inhibition activity of BCL6, but does not affect the protein level of bcl6. 79-6 binds to an aromatic hydrocarbon pocket located in the lateral groove of the BTB region, inducing the destruction of the BCL6 transcriptional complex, reactivating the BCL6 target gene and selectively killing bcl6-dependent DLBCL cells. BCL6 interacts with MTA3 through the RD2 region, inhibiting terminal differentiation. BCL6 recruits CtBP through its DBD region, inhibiting its own activity. In MCF-7 and MDA231 cells, 79-6 inhibited cell invasion and colony formation, and enhanced E-cadherin mRNA expression by inhibiting bcl6. In breast cancer cells, 79-6 can reverse the function of BCL6 in the process of up-regulation of mesenchymal transition (EMT), cell invasion and E-cadherin transcriptional repression. |
| In vivo study | Administration (79-6,50 mg/kg/day) to SCID mice bearing bcl6-dependent DLBCL xenografts caused a 65-70% reduction in stage tumor size, however, there was no effect on non-bcl6-dependent DLBCL xenografts. In Vivo, 79-6 inhibition of BCL6 is an effective anti-lymphoma strategy. |
301356-95-6 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.187 ml | 10.934 ml | 21.868 ml |
| 5 mM | 0.437 ml | 2.187 ml | 4.374 ml |
| 10 mM | 0.219 ml | 1.093 ml | 2.187 ml |
| 5 mM | 0.044 ml | 0.219 ml | 0.437 ml |
Last Update：2024-01-02 23:10:35
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Mobile: 18021002903
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