304896-28-4

Name	2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
Synonyms	AGK2 AGK 2 AGK-2 CS-2248 SRA737, PNT-737 SIRT2 Inhibitor, AGK2 2-Cyano-3-(5-(2,5-dichlorophenyl)furan-2-yl)-N-(quinolin-5-yl)acrylamide 2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide 2-Propenamide, 2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-
CAS	304896-28-4

Molecular Formula	C23H13Cl2N3O2
Molar Mass	434.27
Density	1.445±0.06 g/cm3(Predicted)
Boling Point	675.1±55.0 °C(Predicted)
Solubility	DMSO: soluble2mg/mL, clear (warmed)
Appearance	Yellow solid
Color	White to Yellow to Orange
pKa	8.87±0.43(Predicted)
Storage Condition	room temp
In vitro study	In SIRT2-myc-expressed HeLa cells, AGK2 potently inhibits SIRT2 activity and increases acetylation of tubulin. In primary midbrain medium, AGK2 protects dopaminergic neurons from α-syn-induced toxicity. AGK2 induces cell necrosis and caspase-3-dependent apoptosis in C6 glioma cells. SIRT2 also reduced the viability of merlin-mutant mouse schwann cells (MSCs) without substantially reducing the viability of wild-type MSC.
In vivo study	In a Drosophila model of Parkinson's disease, AGK2 scavenges α-syn-mediated toxicity and amends polymerization.

Hazard Symbols	Xi - Irritant
Risk Codes	36 - Irritating to the eyes
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany	3