30879-49-3

30879-49-3 - Names and Identifiers

Name	1-(5-hydroxy-2-nitrophenyl)ethanone
Synonyms	MFCD12827423 2-Nitro-5-hydroxyacetophenone 5'-Hydroxy-2'-nitroacetophenone 1-(5-hydroxy-2-nitrophenyl)ethanone 1-(5-hydroxy-2-nitrophenyl)ethanone Ethanone, 1-(5-hydroxy-2-nitrophenyl)- ethanone, 1-(5-hydroxy-2-nitrophenyl)- 1-(5-hydroxy-2-nitrophenyl)ethan-1-one
CAS	30879-49-3
InChI	InChI=1/C8H7NO4/c1-5(10)7-4-6(11)2-3-8(7)9(12)13/h2-4,11H,1H3

30879-49-3 - Physico-chemical Properties

Molecular Formula	C8H7NO4
Molar Mass	181.15
Density	1.380
Melting Point	146-147 °C(Solv: ethyl acetate (141-78-6))
Boling Point	391.2±32.0 °C(Predicted)
Flash Point	178.1°C
Vapor Presure	1.12E-06mmHg at 25°C
pKa	6.20±0.10(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.596

30879-49-3 - Introduction

1-(5-hydroxy-2-nitrophenyl)ethanone, chemical formula C8H7NO4, is an organic compound. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: 1-(5-hydroxy-2-nitrophenyl)ethanone is a yellow to orange crystalline solid.
-Melting point: Its melting point is about 152-153 degrees Celsius.
-Solubility: It is soluble in organic solvents such as ethanol, dimethylformamide and dichloromethane, but has low solubility in water.

Use:
-Reagents in Chemical Reactions: 1-(5-hydroxy-2-nitrophenyl)ethanone can be used as reagents in organic synthesis, such as as substrates for amination reactions or starting materials for reduction reactions.
-Drug synthesis: It can also be used as an intermediate in the pharmaceutical field for the synthesis of some drug varieties.

Preparation Method:
The preparation method of 1-(5-hydroxy-2-nitrophenyl)ethanone generally includes the following steps:
1. Starting from p-nitrobenzene, it is treated with alkaline solution to generate negative ions;
2. Under appropriate conditions, the alkylation reaction was carried out to synthesize 1-bromo-4-nitrobenzene;
3. Finally, 1-(5-hydroxy-2-nitrophenyl)ethanone was obtained by cyclization reaction.

Safety Information:
-Limited data on toxicity and harmfulness of 1-(5-hydroxy-2-nitrophenyl)ethanone. It can cause irritation to the eyes and skin, so when using it, it must avoid skin and eye contact and operate in a well-ventilated place.
-During operation, it is necessary to wear appropriate personal protective equipment, such as laboratory gloves, protective glasses, etc.
-When handling 1-(5-hydroxy-2-nitrophenyl)ethanone, follow laboratory safety operating procedures and ensure proper waste disposal and environmental protection measures.

Last Update：2024-04-09 21:00:56