31036-80-3
Lofexidine
CAS: 31036-80-3
Molecular Formula: C11H12Cl2N2O
31036-80-3 - Names and Identifiers
31036-80-3 - Physico-chemical Properties
| Molecular Formula | C11H12Cl2N2O |
| Molar Mass | 259.13 |
| Density | 1.39±0.1 g/cm3(Predicted) |
| Melting Point | 126-128° |
| Boling Point | 421.5±35.0 °C(Predicted) |
| Flash Point | 208.7°C |
| Vapor Presure | 6.35E-07mmHg at 25°C |
| pKa | 9.80±0.40(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Refractive Index | 1.61 |
| Physical and Chemical Properties | Crystallization, melting point 126~128 deg C. Lofexidine Hydrochloride: C11H12(Cl2N2O? HCl. [21498-08-8]. Crystals from ethanol-diethyl ether or 2-propanol, melting point 221-223 °c; There are also melting points 230-232 °c. Very soluble in water or ethanol, slightly soluble in 2-propanol, a few insoluble in ether. Acute toxicity LD50 mice, rats and dogs (mg/kg):74~147 oral; 8~18 intravenous injection. |
31036-80-3 - Nature
Open Data Verified Data
Crystal, melting point 126~128 °c.
Last Update：2024-01-02 23:10:35
31036-80-3 - Preparation Method
Open Data Verified Data
ethyl (-)-2-hydroxypropionate is chlorinated with sulfuryl chloride and then condensed with 2,6-= chlorophenol to react the resulting compound with ethylenediamine, the reaction product was cyclized under the action of titanium tetrachloride to obtain (-)-lofexidine.
Last Update：2022-01-01 09:24:11
31036-80-3 - Use
Open Data Verified Data
britrmia was developed. It was marketed in 1992. Imidazoline derivatives. The structure and function are similar to that of clonidine. Central open adrenal receptor agonists, reduce peripheral sympathetic nerve activity, inhibit the release of norepinephrine, relaxation of vascular smooth muscle, resulting in a decrease in blood pressure. Used to alleviate or relieve the withdrawal syndrome of opioids.
Last Update：2022-01-01 09:24:12
31036-80-3 - Safety
Open Data Verified Data
LDso (mg/kg) in mice, rats and dogs: 74-147 by mouth; 8-18 by intravenous injection.
Last Update：2022-01-01 09:24:12
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