312756-74-4
4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide
CAS: 312756-74-4
Molecular Formula: C20H16Br2N2O3S
312756-74-4 - Names and Identifiers
312756-74-4 - Physico-chemical Properties
| Molecular Formula | C20H16Br2N2O3S |
| Molar Mass | 524.23 |
| Solubility | DMSO: ≥10mg/mL |
| Appearance | powder |
| Color | off-white to light tan |
| Storage Condition | room temp |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Physical and Chemical Properties | Biological activity RS-1 is a compound that stimulates rad51. Can increase the DNA binding activity of rad51. In vitro and in vivo experiments with rabbit embryos, RS-1 enhanced Cas9 and TALEN-mediated knock-in efficiency. |
| Use | Application 4-bromo-n-(4-bromophenyl)-3-[[(phenylmethyl) amino] sulfonyl] benzamide is an intermediate in organic synthesis and pharmaceutical intermediates, can be used in laboratory development processes and chemical production processes. |
| Target | Target Value RAD51 |
| In vitro study | RS-1 stimulates the binding of hRAD51 to ssDNA. A concentration of RS-1 on the micromolar scale enhances DNA binding and results in an extension of the length of the protein-DNA complex. In addition, RS-1 stabilizes the activated form of hrad51. In vitro and in vivo experiments with rabbit embryos, RS-1 enhanced Cas9 and TALEN-mediated knock-in efficiency. |
312756-74-4 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36 - Irritating to the eyes |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
312756-74-4 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.908 ml | 9.538 ml | 19.076 ml |
| 5 mM | 0.382 ml | 1.908 ml | 3.815 ml |
| 10 mM | 0.191 ml | 0.954 ml | 1.908 ml |
| 5 mM | 0.038 ml | 0.191 ml | 0.382 ml |
Last Update：2024-01-02 23:10:35
312756-74-4 - Introduction
4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide is an organic compound with the following properties:
1. Appearance: White crystalline solid.
2. Molecular formula: C14H10Br2N2O3S.
3. Molecular weight: 436.12g/mol.
4. Melting point: 170-172 degrees Celsius.
5. Solubility: Soluble in some organic solvents (such as chloroform, methanol).
The main uses of this compound are:
1. As a pharmaceutical intermediate: it can be used to synthesize biologically active compounds, such as drugs, pesticides, etc.
2. As a dye intermediate: It can be used as an important intermediate in dye synthesis.
The method of preparing 4-Bromo-N-(4-bromophenyl)-3-[[(phenyl methyl)amino]sulfonyl]benzamide includes the following steps:
1. The reaction of phenyl formyl chloride and aniline to generate sulfinate compounds.
2. The sulfinate compound is reacted with hydrobromic acid to generate 4-bromo-n-(4-bromophenyl)-benzamide.
3. Reaction of 4-Bromo-N-(4-bromophenyl)-benzamide with benzyl alcohol yields 4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide.
The following safety information is required when using and handling this compound:
1. This compound may be irritating and corrosive to the eyes, skin and respiratory tract, so appropriate protective measures are required during handling and contact, including wearing protective glasses, gloves and protective masks.
2. Avoid inhaling its dust or gas, and use ventilation equipment when necessary.
3. Avoid exposure to the compound while eating, drinking or smoking.
4. When using this compound, laboratory practices and safe operating procedures should be followed.
5. In the event of an accident or accidental ingestion, seek medical help immediately and provide the safety data sheet of the compound to the medical staff for reference.
1. Appearance: White crystalline solid.
2. Molecular formula: C14H10Br2N2O3S.
3. Molecular weight: 436.12g/mol.
4. Melting point: 170-172 degrees Celsius.
5. Solubility: Soluble in some organic solvents (such as chloroform, methanol).
The main uses of this compound are:
1. As a pharmaceutical intermediate: it can be used to synthesize biologically active compounds, such as drugs, pesticides, etc.
2. As a dye intermediate: It can be used as an important intermediate in dye synthesis.
The method of preparing 4-Bromo-N-(4-bromophenyl)-3-[[(phenyl methyl)amino]sulfonyl]benzamide includes the following steps:
1. The reaction of phenyl formyl chloride and aniline to generate sulfinate compounds.
2. The sulfinate compound is reacted with hydrobromic acid to generate 4-bromo-n-(4-bromophenyl)-benzamide.
3. Reaction of 4-Bromo-N-(4-bromophenyl)-benzamide with benzyl alcohol yields 4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide.
The following safety information is required when using and handling this compound:
1. This compound may be irritating and corrosive to the eyes, skin and respiratory tract, so appropriate protective measures are required during handling and contact, including wearing protective glasses, gloves and protective masks.
2. Avoid inhaling its dust or gas, and use ventilation equipment when necessary.
3. Avoid exposure to the compound while eating, drinking or smoking.
4. When using this compound, laboratory practices and safe operating procedures should be followed.
5. In the event of an accident or accidental ingestion, seek medical help immediately and provide the safety data sheet of the compound to the medical staff for reference.
Last Update：2024-04-09 21:21:28
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Featured ProductsSpot supply
Product Name: RS-1 Visit Supplier Webpage Request for quotationCAS: 312756-74-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: RS-1 Visit Supplier Webpage Request for quotationCAS: 312756-74-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: 4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide Visit Supplier Webpage Request for quotationCAS: 312756-74-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: 4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide Visit Supplier Webpage Request for quotationCAS: 312756-74-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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