31529-27-8
3-(Carboxymethyl)-1H-indole-2-carboxylic acid
CAS: 31529-27-8
Molecular Formula: C11H9NO4
31529-27-8 - Names and Identifiers
| Name | 3-(Carboxymethyl)-1H-indole-2-carboxylic acid |
| Synonyms | 1H-Indole-3-acetic acid, 2-carboxy- 3-(Carboxymethyl)-1H-indole-2-carboxylic acid |
| CAS | 31529-27-8 |
31529-27-8 - Physico-chemical Properties
| Molecular Formula | C11H9NO4 |
| Molar Mass | 219.19 |
| Density | 1.545±0.06 g/cm3(Predicted) |
| Melting Point | 235-236 °C |
| Boling Point | 537.7±35.0 °C(Predicted) |
| pKa | 3.54±0.30(Predicted) |
| Storage Condition | Room Temprature |
| Sensitive | Irritant |
| MDL | MFCD00897387 |
31529-27-8 - Introduction
3-(Carboxymethyl)-1H-indole-2-carboxylic acid is an organic compound with the chemical formula C11H9NO4.
Nature:
3-(Carboxymethyl)-1H-indole-2-carboxylic acid is a pale yellow solid. It is a compound containing a carboxyl group and an indole ring structure. It is acidic and can be dissolved in water.
Use:
3-(carboxymethyl)-1H-indole-2-carboxylic acid has certain application value in the field of medicine. It can be used as an important intermediate in the synthesis of drugs, for the synthesis of various drugs, such as indolamycin antibiotics, anticancer drugs.
Preparation Method:
The preparation of 3-(carboxymethyl)-1H-indole-2-carboxylic acid can be obtained by reacting indole with methanol and dimethyl malonate. The indole is first reacted with methanol under heating to give 3-(carboxymethyl)-lH-indole. The resulting 3-(carboxymethyl)-1H-indole is then subjected to a transesterification reaction with dimethyl malonate to produce 3-(carboxymethyl)-1H-indole-2-ethyl ester, which is hydrolyzed by acid addition to obtain the target product.
Safety Information:
The specific safety information of 3-(carboxymethyl)-1H-indole-2-carboxylic acid is not clear, but as an organic compound, it may be toxic to the human body. In handling and storage, the general safe practice of organic compounds in the laboratory should be observed. During use, wear appropriate protective equipment to avoid contact with skin and eyes. If exposed or ingested, seek medical attention immediately.
Nature:
3-(Carboxymethyl)-1H-indole-2-carboxylic acid is a pale yellow solid. It is a compound containing a carboxyl group and an indole ring structure. It is acidic and can be dissolved in water.
Use:
3-(carboxymethyl)-1H-indole-2-carboxylic acid has certain application value in the field of medicine. It can be used as an important intermediate in the synthesis of drugs, for the synthesis of various drugs, such as indolamycin antibiotics, anticancer drugs.
Preparation Method:
The preparation of 3-(carboxymethyl)-1H-indole-2-carboxylic acid can be obtained by reacting indole with methanol and dimethyl malonate. The indole is first reacted with methanol under heating to give 3-(carboxymethyl)-lH-indole. The resulting 3-(carboxymethyl)-1H-indole is then subjected to a transesterification reaction with dimethyl malonate to produce 3-(carboxymethyl)-1H-indole-2-ethyl ester, which is hydrolyzed by acid addition to obtain the target product.
Safety Information:
The specific safety information of 3-(carboxymethyl)-1H-indole-2-carboxylic acid is not clear, but as an organic compound, it may be toxic to the human body. In handling and storage, the general safe practice of organic compounds in the laboratory should be observed. During use, wear appropriate protective equipment to avoid contact with skin and eyes. If exposed or ingested, seek medical attention immediately.
Last Update：2024-04-09 02:00:56
