317318-96-0

317318-96-0 - Names and Identifiers

Name	{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methanol
Synonyms	4-Methyl-2-[4-(trifluoroMethyl)phenyl]-5-thiazoleMethanol [4-Methyl-2-(4-trifluoroMethylphenyl)thiazol-5-yl]Methanol 5-Thiazolemethanol, 4-methyl-2-[4-(trifluoromethyl)phenyl]- 5-(Hydroxymethyl)-4-methyl-2-(4-trifluoromethylphenyl)thiazole [4-Methyl-2-[4-(trifluoroMethyl)phenyl]-1,3-thiazol-5-yl]Methano (4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL)METHANOL {4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methanol [4- Methyl -2- (4- (Three Fluorine Methyl Phenol -1,3- Thiazole -5- Based Methano [4- methyl -2- (4- (three fluorine methyl) phenol) -1,3- thiazole -5- based methanol
CAS	317318-96-0
EINECS	200-589-5
InChI	InChI=1/C12H10F3NOS/c1-7-10(6-17)18-11(16-7)8-2-4-9(5-3-8)12(13,14)15/h2-5,17H,6H2,1H3

317318-96-0 - Physico-chemical Properties

Molecular Formula	C12H10F3NOS
Molar Mass	273.27
Density	1.359±0.06 g/cm3(Predicted)
Melting Point	120-123°C
Boling Point	380.0±52.0 °C(Predicted)
Flash Point	183.6°C
Solubility	Chloroform (Slightly), Methanol (Slightly)
Vapor Presure	1.89E-06mmHg at 25°C
Appearance	Solid
Color	White to Pale Yellow
pKa	13.47±0.10(Predicted)
Storage Condition	-20°C Freezer
Refractive Index	1.545

317318-96-0 - Risk and Safety

Hazard Note	Harmful
Hazard Class	IRRITANT

317318-96-0 - Introduction

{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methanol, also known as {4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methanol, is an organic compound. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: A white crystalline solid.
-Molecular formula: C13H11F3NOS.
-Molecular weight: 303.29g/mol.
-Melting point: About 80-82 ° C.

Use:
- {4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methanol has certain application potential in drug research, because it combines the characteristics of thiazole ring and benzene ring.
-It can be used as an intermediate for the synthesis of other compounds, such as biologically active compounds or drugs.

Method:
- {4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methanol can be synthesized by a variety of methods, the following is a basic synthetic route:
1. First, 4-amino -2-methyl phenol is reacted with trifluoromethyl benzoic acid to generate 4-(trifluoromethyl)-2-methyl phenol.
2. Esterification of 4-(trifluoromethyl)-2-methylphenol with bromoacetoacetic acid to form 4-methyl -2-(4-(trifluoromethyl) phenol)-1,3-Thiazole.
3. Finally, 4-methyl-2-(4-(trifluoromethyl) phenol)-1,3-thiazole is reacted with methanol, the target product {4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methanol was produced.

Safety Information:
- {4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methanol shall be used and handled in accordance with the safety procedures.
-It may have an irritating effect on the eyes, skin and respiratory system, so appropriate protective measures should be taken when exposed.
-When storing, keep it in a closed container, away from fire and heat sources.
-Before use, carefully read and follow the safety data form (SDS) provided by the supplier.

Last Update：2024-04-09 21:00:56