320-32-1

320-32-1 - Names and Identifiers

Name	4-Hydroxy-2-(trifluoromethyl)benzoic acid
Synonyms	QVR DQ BXFFF [WLN] 2-Trifluoromethyl-4-hydroxybenzoic acid 4-Hydroxy-2-(trifluoromethyl)benzoic acid 4-HYDROXY-2-(TRIFLUOROMETHYL)BENZOIC ACID Benzoic acid, 4-hydroxy-2-(trifluoromethyl)- alpha,alpha,alpha-Trifluoro-4-hydroxy-o-toluic acid 4-Carboxy-3-(trifluoromethyl)phenol, 2-Carboxy-5-hydroxybenzotrifluoride
CAS	320-32-1
InChI	InChI=1/C8H5F3O3/c9-8(10,11)6-3-4(12)1-2-5(6)7(13)14/h1-3,12H,(H,13,14)

320-32-1 - Physico-chemical Properties

Molecular Formula	C8H5F3O3
Molar Mass	206.12
Density	1.539±0.06 g/cm3(Predicted)
Melting Point	159-161°C
Boling Point	322.6±42.0 °C(Predicted)
Flash Point	148.9°C
Water Solubility	Slightly soluble in water.
Vapor Presure	0.000114mmHg at 25°C
pKa	3.60±0.36(Predicted)
Refractive Index	1.509

320-32-1 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	R36 - Irritating to the eyes R51 - Toxic to aquatic organisms
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Hazard Note	Irritant

320-32-1 - Introduction

4-Hydroxy-2-(trifluoromethyl)benzoic acid, also known as 4-Hydroxy-2-(trifluoromethyl)benzoic acid, chemical formula C8H5F3O3.

Nature:
-Appearance: White Crystal
-Melting Point: 165-169 ° C
-Solubility: Soluble in alcohol and Ester solvents
-Relative density: 1.632
-Molecular weight: 214.12

Use:
4-Hydroxy-2-(trifluoromethyl)benzoic acid has certain application value in chemical synthesis. Mainly used in the synthesis of drugs, dyes and denaturants.
In organic synthesis, it is usually used as a catalyst or intermediate, which can cause the exchange reaction of aromatic carbon-carbon bonds, thereby realizing the construction and change of carbon-carbon bonds.

Method:
4-Hydroxy-2-(trifluoromethyl)benzoic acid has a variety of synthetic methods, the following is one of the commonly used synthetic routes:
1. First, benzoic acid is reacted with trifluoromethyl benzoic anhydride in acetic acid to generate benzoyl trifluoric anhydride.
2. Then, benzoyltrifluorocarboxylic anhydride is reacted with hydroxylamine to generate 4-hydroxy-2-trifluoromethylbenzamide.
3. Finally, 4-hydroxy-2-trifluoromethylbenzamide is subjected to acid hydrolysis to obtain the target product 4-Hydroxy-2-(trifluoromethyl)benzoic acid.

Safety Information:
4-Hydroxy-2-(trifluoromethyl)benzoic acid is a chemical and should be used and stored correctly. Wear appropriate personal protective equipment such as gloves, goggles and protective clothing during operation. Avoid contact with skin, eyes and respiratory tract. In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical help. When storing, store it in a dry, cool place, away from fire and flammable materials.

Last Update：2024-04-09 21:01:54