32175-00-1
trans-4-Methyl Cyclohexyl Isocyanate
CAS: 32175-00-1;38258-74-1
Molecular Formula: C8H13NO
32175-00-1 - Names and Identifiers
32175-00-1 - Physico-chemical Properties
| Molecular Formula | C8H13NO |
| Molar Mass | 139.19 |
| Density | 1.04 |
| Boling Point | 182°C |
| Flash Point | 60°C |
| Vapor Presure | 0.818mmHg at 25°C |
| Refractive Index | 1.518 |
| Physical and Chemical Properties | Colorless transparent liquid. |
| Use | Used as an intermediate of glimepiride |
32175-00-1 - Reference Information
| Preparation method | Using p-cresol as raw material, it is reduced by Raney Ni/ H2, sodium hypochlorite oxidation, oxime, and Zn/acetic acid to obtain trans-4-methylcyclohexylamine, and then react with triphosgene to obtain trans-4-methylcyclohexyl isocyanate. The raw materials are easily available, the reaction conditions at each step are mild, the operation is convenient, and the total yield is 34.5%. |
| Use | Used as an intermediate for the drug glimepiride |
Last Update：2024-04-09 15:16:45
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