32222-48-3
D-2-fluoro mandelic acid
CAS: 32222-48-3
Molecular Formula: C8H7FO3
32222-48-3 - Names and Identifiers
| Name | D-2-fluoro mandelic acid |
| Synonyms | (R)-(-)-Miandelic acid D-2-fluoro mandelic acid D-2-fluoro Mandelic acid (R)-2-FLUOROMANDELIC ACID R-(-)-2-fluoro mandelic acid (2S)-(2-fluorophenyl)(hydroxy)ethanoic acid (R)-2-(2-Fluorophenyl)-2-hydroxyacetic acid (2R)-2-(2-fluorophenyl)-2-hydroxyacetic acid Benzeneacetic acid, 2-fluoro-α-hydroxy-, (αR)- |
| CAS | 32222-48-3 |
| InChI | InChI=1/C8H7FO3/c9-6-4-2-1-3-5(6)7(10)8(11)12/h1-4,7,10H,(H,11,12)/t7-/m0/s1 |
32222-48-3 - Physico-chemical Properties
| Molecular Formula | C8H7FO3 |
| Molar Mass | 170.14 |
| Density | 1.425±0.06 g/cm3(Predicted) |
| Melting Point | 88-90 °C |
| Boling Point | 314.8±27.0 °C(Predicted) |
| Flash Point | 144.2°C |
| Vapor Presure | 0.000192mmHg at 25°C |
| pKa | 3.33±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.565 |
32222-48-3 - Introduction
D-2-fluoro mandelic acid(D-2-fluoro mandelic acid) is an organic compound. Its chemical formula is C8H7FO3, and its structure contains a fluorine atom and a hydroxyl group.
D-2-fluoro mandelic acid can form white crystals in different solvents. It has moderate solubility and is soluble in water and common organic solvents such as alcohols and ethers. Its melting point is about 160-164 degrees Celsius.
D-2-fluoro mandelic acid is widely used in the field of medicine. It is used as an intermediate in the synthesis of chemicals and pharmaceuticals. Commonly used in the manufacture of anti-infective drugs and high blood pressure drugs. In addition, it can also be used as a stereoselective catalyst.
There are many methods for preparing D-2-fluoro mandelic acid, and the commonly used methods are catalytic fluorination and hydroxyl protection reaction. In catalytic fluorination, the D-2-fluoro mandelic acid is obtained by using fluorinating agent and catalyst to promote the reaction of O-fluorobenzoic acid with methanol. The reaction law of hydroxyl protection is to react the hydroxyl compound with a reactant with a protecting group to obtain the D-2-fluoro mandelic acid.
For safety information, there is relatively little specific toxicity data D-2-fluoro mandelic acid. However, it is generally believed that exposure to or inhalation of large amounts of D-2-fluoro mandelic acid may have adverse health effects, such as irritation to the eyes, respiratory tract and skin. Therefore, when using and handling D-2-fluoro mandelic acid, appropriate protective measures should be taken, such as wearing gloves, safety glasses and masks. For laboratory and industrial use, it is also necessary to dispose of waste in accordance with relevant regulations.
D-2-fluoro mandelic acid can form white crystals in different solvents. It has moderate solubility and is soluble in water and common organic solvents such as alcohols and ethers. Its melting point is about 160-164 degrees Celsius.
D-2-fluoro mandelic acid is widely used in the field of medicine. It is used as an intermediate in the synthesis of chemicals and pharmaceuticals. Commonly used in the manufacture of anti-infective drugs and high blood pressure drugs. In addition, it can also be used as a stereoselective catalyst.
There are many methods for preparing D-2-fluoro mandelic acid, and the commonly used methods are catalytic fluorination and hydroxyl protection reaction. In catalytic fluorination, the D-2-fluoro mandelic acid is obtained by using fluorinating agent and catalyst to promote the reaction of O-fluorobenzoic acid with methanol. The reaction law of hydroxyl protection is to react the hydroxyl compound with a reactant with a protecting group to obtain the D-2-fluoro mandelic acid.
For safety information, there is relatively little specific toxicity data D-2-fluoro mandelic acid. However, it is generally believed that exposure to or inhalation of large amounts of D-2-fluoro mandelic acid may have adverse health effects, such as irritation to the eyes, respiratory tract and skin. Therefore, when using and handling D-2-fluoro mandelic acid, appropriate protective measures should be taken, such as wearing gloves, safety glasses and masks. For laboratory and industrial use, it is also necessary to dispose of waste in accordance with relevant regulations.
Last Update：2024-04-09 20:52:54
