324523-20-8

324523-20-8 - Names and Identifiers

Name	2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride
Synonyms	NPS2143 NPS 2143 HCL NPS-2143 HCL NPS-2143 (Mono HCl) SB-262470-A hydrochloride NPS-2143 hydrochloride (SB-262470A) 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride
CAS	324523-20-8

324523-20-8 - Physico-chemical Properties

Molecular Formula	C24H26Cl2N2O2
Molar Mass	445.38
Solubility	DMSO: >10mg/mL
Appearance	powder
Color	white to beige
Storage Condition	2-8°C
In vitro study	NPS-2143 hydrochloride (SB-262470A hydrochloride) stimulates parathyroid hormone (PTH) secretion from bovine parathyroid cells with EC 50 of 41 nM. Moreover, NPS-2143 hydrochloride also blocks the inhibitory effects of calcimimetic NPS R-467 on PTH secretion from bovine parathyroid cells and the inhibitory effects of extracellular Ca2+ on isoproterenol-stimulated increases in cyclic AMP formation.
In vivo study	When infused intravenously in normal rats, NPS-2143 hydrochloride (SB-262470A hydrochloride) causes a rapid and large increase in plasma levels of PTH. Ca 2+ receptor antagonists are termed calcilytics and NPS-2143 is the first substance (either atomic or molecular) shown to possess such activity. When administered together with an antiresorptive agent (estradiol), NPS 2143 causes an increase in trabecular bone volume and bone mineral density in osteopenic rats.

324523-20-8 - Risk and Safety

Risk Codes	R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Description	S36/37 - Wear suitable protective clothing and gloves. S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets.
UN IDs	UN 3077 9 / PGIII
WGK Germany	3

324523-20-8 - References

biological activity

NPS-2143 hydrochloride (SB-262470A hydrochloride), an orally active calcium-dissolving agent, is a selective calcium-sensing receptor (CaSR). Antagonist. NPS-2143 hydrochloride (SB-262470A hydrochloride) increases cytoplasmic Ca2 concentration by activating Ca2 receptors in HEK 293 cells that express human Ca2 receptors (IC50=43 nM).

Last Update：2024-04-09 18:58:34