325457-99-6
ICA 110381
CAS: 325457-99-6
Molecular Formula: C12H8Cl2N2O
325457-99-6 - Names and Identifiers
325457-99-6 - Physico-chemical Properties
| Molecular Formula | C12H8Cl2N2O |
| Molar Mass | 267.11 |
| Solubility | ( < 1 mg/ml refers to the product slightly soluble or insoluble) |
| Appearance | solid |
| Color | White |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| Use | ICA 110381 (Compound 16) is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. ICA 110381 is a KCNQ2/Q3 agonist with EC50 of 0.38 μM and KCNQ1 antagonist with IC50 of 15 μM, respectively. |
| Target | KCNQ2/Q3; KCNQ1 |
325457-99-6 - Reference
| Reference Show more | 1. Amato G , Roeloffs R , Rigdon G C , et al. N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy[J]. ACS Medicinal Chemistry Letters, 2011, 2(6):481. |
325457-99-6 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.744 ml | 18.719 ml | 37.438 ml |
| 5 mM | 0.749 ml | 3.744 ml | 7.488 ml |
| 10 mM | 0.374 ml | 1.872 ml | 3.744 ml |
| 5 mM | 0.075 ml | 0.374 ml | 0.749 ml |
Last Update：2024-01-02 23:10:35
325457-99-6 - Reference Information
| biological activity | ICA 110381 (Compound 16) is a opener for the KCNQ2/Q3 silicone channel for the treatment of epilepsy. ICA 110381 exhibited agonist activity against KCNQ2/Q3 with an EC50 value of 0.38 μm and antagonist activity against KCNQ1 with an IC50 value of 15 μm. |
| Target | Value |
| KCNQ2/Q3 (Cell-free assay) | 0.38 μM(EC50) |
| KCNQ1 (Cell-free assay) | 15 μM |
Last Update：2024-04-09 21:01:54
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Spot supply
Product Name: ICA 110381 Visit Supplier Webpage Request for quotationCAS: 325457-99-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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