328-38-1
(2S)-2-amino-4-methyl-pentanoic acid
CAS: 328-38-1
Molecular Formula: C6H13NO2
328-38-1 - Names and Identifiers
| Name | (2S)-2-amino-4-methyl-pentanoic acid |
| Synonyms | D-LEU D-Leu D-LEUCINE D-Leucine H-D-Leu-OH (S)-Leucine H-D-Leucine (R)-LEUCINE D-HOMO-VALINE (S)-(+)-Leucine (R)-(-)-LEUCINE 2S)-alpha-leucine 4-Methyl-norvaline (S)-2-Amino-4-methylvaleric acid (R)-2-AMINO-4-METHYLVALERIC ACID 2-Amino-4-methylvaleric acid (L) (R)-2-AMINO-4-METHYLPENTANOIC ACID 2-Amino-4-methylpentanoic acid (L) (2S)-2-amino-4-methyl-pentanoic acid 2-Amino-4-methylpentanoic acid, (S)- |
| CAS | 328-38-1 |
| EINECS | 206-327-7 |
| InChI | InChI=1/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m1/s1 |
328-38-1 - Physico-chemical Properties
| Molecular Formula | C6H13NO2 |
| Molar Mass | 131.17 |
| Density | 1.2930 (estimate) |
| Melting Point | >300°C(lit.) |
| Boling Point | 225.8±23.0 °C(Predicted) |
| Specific Rotation(α) | -15.45 º (c=4, 6N HCl) |
| Flash Point | 90.3°C |
| Water Solubility | 24 g/L (25 ºC) |
| Solubility | Aqueous Acid (Sparingly), Water (Slightly) |
| Vapor Presure | 0.0309mmHg at 25°C |
| Appearance | White crystal |
| Color | White |
| BRN | 1721721 |
| pKa | 2.55±0.21(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | -15 ° (C=4, 6mol/L H |
| MDL | MFCD00063088 |
| Physical and Chemical Properties | White scaly crystal or crystalline powder; Soluble in water and acetic acid, slightly soluble in ethanol, insoluble in ether; pI5.98, heated to 145-147 ℃ to begin sublimation, the decomposition point is 293-295 ℃; Relative density of 1.293, specific rotation [α]20D-10.34 °(0.5-2.0 mg/ml,H2O), [α]20D-15.6 °(0.5-2.0 mg/ml,5 mol/L HCl),LD50 (rat, intraperitoneal) 642 mg/kg. |
| In vitro study | In a screen of candidate neuronal receptors, D-leucine failed to compete for binding by cognate ligands, potentially suggesting a novel target. Even at low doses, D-leucine suppressed ongoing seizures at least as effectively as diazepam but without sedative effects. These studies raise the possibility that D-leucine may represent a new class of anti-seizure agents, and that D-leucine may have a previously unknown function in eukaryotes. |
328-38-1 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | OH2840000 |
| TSCA | Yes |
| HS Code | 29224995 |
328-38-1 - Reference
| Reference Show more | 1. [IF=7.1] Haiyan Fu et al."Rational design of an “on-off-on” fluorescent assay for chiral amino acids based on quantum dots and nanoporphyrin."Sensor Actuat B-Chem. 2019 May;287:1 2. [IF=7.79] Ye Lu et al."Enhancing hydrogel-based long-lasting chemiluminescence by a platinum-metal organic framework and its application in array detection of pesticides and D-amino acids."Nanoscale. 2020 Feb;12(8):4959-4967 3. [IF=4.759] Lixia Chen et al."Theoretical electronic circular dichroism investigations of chiral amino acids and development of separation and identification methods independent of standards."J Chromatogr A. 2021 Sep;1654:462446 |
328-38-1 - Standard
Authoritative Data Verified Data
This product is L-2-amino -4-methyl pentanoic acid. Calculated as dried product, the content of C6H13NO2 shall not be less than 98.5%.
Last Update：2024-01-02 23:10:35
328-38-1 - Trait
Authoritative Data Verified Data
- This product is white crystal or crystalline powder; Odorless.
- This product is soluble in formic acid, slightly soluble in water, and slightly soluble in ethanol or ether.
specific rotation
take this product, precision weighing, add 6mol/L hydrochloric acid solution to dissolve and quantitatively dilute to make a solution containing about 40mg per lml, and determine according to law (General 0621), the specific rotation is 14. 9 ° to ten 16.0 °.
Last Update：2022-01-01 14:18:54
328-38-1 - Introduction
Solubility in water: 24g/l (25°C), slightly soluble in alcohol, insoluble in ether.
Last Update：2022-10-16 17:24:37
328-38-1 - Differential diagnosis
Authoritative Data Verified Data
- take the appropriate amount of this product and the reference substance of leucine, respectively add water to dissolve and dilute to make a solution containing about 0.4mg per 1 ml, as the test solution and the reference solution, test according to the chromatographic conditions under other amino acids. The position and color of the main spot displayed by the test solution should be the same as that of the reference solution.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 987).
Last Update：2022-01-01 14:18:54
328-38-1 - Exam
Authoritative Data Verified Data
acidity
take 0.50g of this product, add 50ml of water, heat to dissolve, cool, and determine according to law (General 0631),pH value should be 5.5~6.5.
transmittance of solution
take 0.50g of this product, add 50ml of water, heat to dissolve, cool, ultraviolet-visible spectrophotometry (General rule 0401), measure the transmittance at 430nm wavelength, not less than 98.0%.
chloride
take 0.25g of this product and check it according to law (General rule 0801). Compared with the control solution made of 5.0 ml of standard sodium chloride solution, it should not be more concentrated (0.02%).
sulfate
take l.Og of this product and check it according to law (General rule 0802). Compared with the control solution made of 2.0 ml of standard potassium sulfate solution, it should not be more concentrated (0.02%).
ammonium salt
take this product 0. Log, check according to law (General rule 0808), and compare with the control solution made of standard ammonium chloride solution 2.0 ML, not deeper (0.02%).
Other amino acid
take an appropriate amount of this product, add water to dissolve and dilute to make a solution containing about 20mg per lml as a test solution; Take 1ml for precision measurement and put it in a 200ml measuring flask, dilute to the scale with water, shake, as a control solution; Take the appropriate amount of the leucine reference and the valine reference, and put it in the same measuring flask, water was added to dissolve and diluted to prepare a solution containing about 0.4mg each per 1ml as a system-suitable solution. According to the thin layer chromatography (General 0502) test, absorb the above three solutions each 5 u1, respectively, on the same silica gel G thin layer plate, with n-butanol-water-glacial acetic acid (3:1:1) for development, after deployment, air-drying, spraying with ninhydrin in acetone solution (1-50), heating at 80°C until spots appear, and examination immediately. The control solution should show a clear spot, and the system applicable solution should show two completely separated spots. If the test solution shows impurity spots, the color should not be deeper (0.5%) than the main spot of the control solution.
loss on drying
take this product, dry at 105°C for 3 hours, loss of weight shall not exceed 0.2% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Iron Salt
take 1.5g of this product and check it according to law (General rule 0807). Compared with the control solution made of 0.001% of standard iron solution, it shall not be deeper ().
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
arsenic salt
add 5ml water, 1ml sulfuric acid and 10ml sulfurous acid, heat to a volume of about 2ml in a water bath, add 5ml water, add Dropwise ammonia solution until the indicator of phenolphthalein is neutral, add hydrochloric acid 5ml, add water to make 28ml, according to the law inspection (General Principles 0822 The first law), should comply with the provisions (0.0001%).
bacterial endotoxin
take this product, check according to law (General 1143), each lg leucine containing endotoxin should be less than 25EU. (For injection)
Last Update：2022-01-01 14:18:55
328-38-1 - Content determination
Authoritative Data Verified Data
take this product about 0.lg, precision weighing, add anhydrous formic acid 1 ml dissolved, add glacial acetic acid 25ml, according to the potentiometric titration method (General rule 0701), with perchloric acid titration solution (O. 1 mol/L) titration, and the results of the titration were corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 13.12mg of C6H13N02.
Last Update：2022-01-01 14:18:55
328-38-1 - Category
Authoritative Data Verified Data
amino acid drugs.
Last Update：2022-01-01 14:18:56
328-38-1 - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 14:18:56
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