329214-79-1
3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine
CAS: 329214-79-1
Molecular Formula: C11H16BNO2
329214-79-1 - Names and Identifiers
329214-79-1 - Physico-chemical Properties
| Molecular Formula | C11H16BNO2 |
| Molar Mass | 205.06 |
| Density | 1.03±0.1 g/cm3(Predicted) |
| Melting Point | 102-104.4°C(lit.) |
| Boling Point | 300.9±15.0 °C(Predicted) |
| Flash Point | 135.8°C |
| Water Solubility | Insoluble |
| Vapor Presure | 0.00195mmHg at 25°C |
| Appearance | Crystalline Powder |
| Color | White |
| pKa | 5.22±0.12(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.489 |
| MDL | MFCD03084758 |
329214-79-1 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29333990 |
| Hazard Class | IRRITANT |
329214-79-1 - Reference Information
| application | 3-pyridine boric acid pinacol ester occupies an important position as a pharmaceutical intermediate and has potential biological activity in clinic. |
| preparation | anhydrous tetrahydrofuran (THF, 5 ml) is added, and 2-isopropyl -4,4,5, 5-tetramethyl-1, 3, 2-dioxyborane (1.5 mmol) is added. Finally, 1, 2-dibromoethane (1.0 mmol) was added to the obtained mixture. The reaction mixture was stirred at room temperature for 3 hours. After the reaction is completed, the reaction mixture is sucked and filtered to collect the filtrate. After adding saturated NaCl solution (20 ml), the filtrate was extracted several times with dichloromethane (CH2Cl2, 20 ml). The organic layer is separated, dried on magnesium sulfate, concentrated under reduced pressure, and the solvent is removed to obtain a purified product. The steps of Example 2 are repeated, except that 1, 2-dimethylene is replaced with 1, 2-diiodoethane, iodine, lewis acid and other activators; the metal is Mg, Li, Zn, Cu or Cu/Zn alloy; Ether replaces tetrahydrofuran as solvent. The final product, pyridine-3-borate, is obtained. |
Last Update：2024-04-10 22:29:15
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Product Name: 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Pyridine Visit Supplier Webpage Request for quotationCAS: 329214-79-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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