330161-87-0
SU6656
CAS: 330161-87-0
Molecular Formula: C19H21N3O3S
330161-87-0 - Names and Identifiers
330161-87-0 - Physico-chemical Properties
| Molecular Formula | C19H21N3O3S |
| Molar Mass | 371.45 |
| Density | 1.378±0.06 g/cm3(Predicted) |
| Solubility | DMSO: 18.5 mg/mL |
| Appearance | powder |
| Color | orange-brown |
| pKa | 11.87±0.20(Predicted) |
| Storage Condition | -20°C |
| In vitro study | In NIH 3T3 cells, SU 6656 inhibited PDGF-mediated S-phase induction with IC50 values of 0.3-0.4 μm. In normal and colony stimulating factor 1 receptor-transfected NIH 3T3 cells, SU 6656 inhibits PDGF and serum-mediated NIH 3T3 cell proliferation and epidermal growth factor and colony stimulating factor 1-induced DNA synthesis. SU6656 inhibited PDGF-induced c-Myc sensing and ERK2 activity. Pretreatment of Jurkat T cells with SU 6656 increased luciferase activity by VSV-G. In proximal renal tubular epithelial cells, SU 6656 attenuates TGF-β-mediated upregulation of CTGF mRNA and protein and also reduces CTGF expression in cells exposed to autocrine growth factors. SU 6656 can interfere with Aurora kinase activity, resulting in inhibition of cell division and formation of multi-leaf nuclei. |
| In vivo study | SU 6656 significantly dose-dependently inhibited mecanylamine-induced experimental nicotine withdrawal syndrome in WSS and Anxiety score measuring mice. SU 6656(1.5, 3 and 6 mg/kg, I. P.) administered once daily significantly dose-dependently inhibited naloxone-mediated morphine withdrawal syndrome. |
330161-87-0 - Risk and Safety
| WGK Germany | 3 |
330161-87-0 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.692 ml | 13.461 ml | 26.921 ml |
| 5 mM | 0.538 ml | 2.692 ml | 5.384 ml |
| 10 mM | 0.269 ml | 1.346 ml | 2.692 ml |
| 5 mM | 0.054 ml | 0.269 ml | 0.538 ml |
Last Update：2024-01-02 23:10:35
330161-87-0 - Introduction
SU6656 is a small molecule compound with the chemical name 2-[(3,5-Dichloro-phenyl)-amino]-4 '-ethynyl-phenylamino]-6'-prop-2-enyl-3 '5'-quinoline-trione. It has the appearance of white to pale yellow crystals. The following is a description of the nature, use, preparation and safety information of SU6656:
Nature:
-Appearance: White to light yellow crystal
-Molecular formula: C28H19Cl2N5O3
-Molecular weight: 537.39g/mol
-Solubility: Soluble in organic solvents such as DMSO and ethanol
Use:
SU6656 is a selective Src kinase inhibitor. It can be used to study biological processes such as cell signaling, cell proliferation and apoptosis. SU6656 is also used as a candidate compound for drug development, with potential therapeutic applications such as anti-cancer, anti-inflammatory and immunosuppressive.
Preparation Method:
Regarding the preparation method of SU6656, it is usually obtained by chemical synthesis. Specifically, it is synthesized by a multi-step reaction involving the reaction of phenylacetylene and 2-amino -4 '-amino -6'-propyn-3 ',5'-ketoquinoline.
Safety Information:
- SU6656 is a laboratory reagent and is used in accordance with appropriate laboratory procedures and personal protective measures.
-It should be kept away from fire and heat sources, and stored in a dry, cool place.
-After contact with the compound, the contaminated area should be thoroughly cleaned to avoid inhalation of dust or skin contact.
-There are limited studies on the toxicity and safety of SU6656, so care should be taken when using it and handle it in accordance with the instructions on the relevant Material Safety Data Sheet (MSDS).
Nature:
-Appearance: White to light yellow crystal
-Molecular formula: C28H19Cl2N5O3
-Molecular weight: 537.39g/mol
-Solubility: Soluble in organic solvents such as DMSO and ethanol
Use:
SU6656 is a selective Src kinase inhibitor. It can be used to study biological processes such as cell signaling, cell proliferation and apoptosis. SU6656 is also used as a candidate compound for drug development, with potential therapeutic applications such as anti-cancer, anti-inflammatory and immunosuppressive.
Preparation Method:
Regarding the preparation method of SU6656, it is usually obtained by chemical synthesis. Specifically, it is synthesized by a multi-step reaction involving the reaction of phenylacetylene and 2-amino -4 '-amino -6'-propyn-3 ',5'-ketoquinoline.
Safety Information:
- SU6656 is a laboratory reagent and is used in accordance with appropriate laboratory procedures and personal protective measures.
-It should be kept away from fire and heat sources, and stored in a dry, cool place.
-After contact with the compound, the contaminated area should be thoroughly cleaned to avoid inhalation of dust or skin contact.
-There are limited studies on the toxicity and safety of SU6656, so care should be taken when using it and handle it in accordance with the instructions on the relevant Material Safety Data Sheet (MSDS).
Last Update：2024-04-09 21:54:55
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Spot supply
Product Name: SU6656 Visit Supplier Webpage Request for quotationCAS: 330161-87-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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