33089-15-5

Name	4-chloro-2-(methylsulfanyl)pyrimidine-5-carbonitrile
Synonyms	4-Chloro-2-methylthio-5-cyanopyrimidine 4-Chloro-2-(methylthio)pyrimidine-5-carbonitrile 4-chloro-2-(methylthio)-5-pyrimidinecarbonitrile 5-Pyrimidinecarbonitrile, 4-chloro-2-(methylthio)- 4-Chloro-2-methylsulfanyl-pyrimidine-5-carbonitrile 4-chloro-2-(methylsulfanyl)pyrimidine-5-carbonitrile 4-Chloro-2-(methylsulfanyl)pyrimidine-5-carbonitrile 4-Chloro-2-(methylsulphanyl)pyrimidine-5-carbonitrile 4-Chloro--2-methylsulfanyl-pyrimididine-5-carbonitrile
CAS	33089-15-5
EINECS	813-495-0
InChI	InChI=1/C6H4ClN3S/c1-11-6-9-3-4(2-8)5(7)10-6/h3H,1H3

Molecular Formula	C6H4ClN3S
Molar Mass	185.63
Density	1.45±0.1 g/cm3(Predicted)
Melting Point	67-68 °C(Solv: benzene (71-43-2); ligroine (8032-32-4))
Boling Point	340.7±22.0 °C(Predicted)
Flash Point	159.878°C
Vapor Presure	0mmHg at 25°C
pKa	-3.26±0.29(Predicted)
Storage Condition	Inert atmosphere,Store in freezer, under -20°C
Refractive Index	1.614

Risk Codes	R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S9 - Keep container in a well-ventilated place. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves.
UN IDs	3439
HS Code	29335990

introduction	pyrimidine is a very important heterocyclic compound, which is widely used in the fields of medicine and pesticides. Because pyrimidine compounds have the advantages of high efficiency, low toxicity and unique mode of action, their molecular design, synthesis and biological activity research are still a very active field in the research of heterocyclic compounds. Pyrimidine derivatives are used as receptor tyrosine kinase inhibitors and are used in the treatment of cancer. 4-Chloro-2-methylthiopyrimidin-5-nitrile is a heterocyclic organic compound that can be used as a pharmaceutical intermediate.
Use	4-chloro-2-methylthiopyrimidine-5-nitrile is an organic intermediate. It has been reported that 4-chloro-2-methylthiopyrimidin-5-nitrile can be used to prepare steroidal anti-androgen compounds. Pharmacological experiments have proved that these compounds have good anti-prostate cancer activity.
preparation	2g(6.6mmol) of raw material 4-chloro-2-methylthiopyrimidine -5-carboxylate ethyl ester is dissolved in 10ml of anhydrous ethanol, 0.68g of NaOH solid and 10ml of water are added, and the temperature is heated to reflux. TLC showed complete response after 1h. Rotate and dry the ethanol, adjust the PH to 3 with 6N HCl, and a large amount of solid is precipitated. 1.69g of white crystal was obtained by suction filtration with 91.8% yield.

Last Update：2024-04-10 22:29:15

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Product Name: 4-chloro-2-(methylsulfanyl)pyrimidine-5-carbonitrile Request for quotation
CAS: 33089-15-5
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756

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33089-15-5

33089-15-5 Request for Quotation