Name | Madecassoside |
Synonyms | Asiaticoside A O-6-Deoxy-alpha-L-mannopyranosyl-(1.4)-O-beta-D-glucopyranosyl-(1.6)-beta-D-glucopyranosyl (2alpha,3beta,4alpha,6beta)-2,3,6,23-tetrahydroxyurs-12-en-28-oate |
CAS | 34540-22-2 |
EINECS | 252-076-1 |
InChI | InChI=1/C48H78O20/c1-19-10-11-48(13-12-46(6)22(28(48)20(19)2)8-9-27-44(4)14-24(52)39(61)45(5,18-50)38(44)23(51)15-47(27,46)7)43(62)68-42-35(59)32(56)30(54)26(66-42)17-63-40-36(60)33(57)37(25(16-49)65-40)67-41-34(58)31(55)29(53)21(3)64-41/h8,19-21,23-42,49-61H,9-18H2,1-7H3 |
InChIKey | BNMGUJRJUUDLHW-CIZDPPTDSA-N |
Molecular Formula | C48H78O20 |
Molar Mass | 975.12 |
Density | 1.47±0.1 g/cm3(Predicted) |
Melting Point | 220-223 °C |
Boling Point | 1043.6±65.0 °C(Predicted) |
Specific Rotation(α) | (c, 2 in H2O)-19 |
Flash Point | 295.8°C |
Solubility | It is soluble in water and ethanol, and insoluble in ether and chloroform. |
Vapor Presure | 0mmHg at 25°C |
Appearance | White crystalline powder |
Color | white to off-white |
pKa | 12.50±0.70(Predicted) |
Storage Condition | 2-8°C |
Stability | Hygroscopic |
Sensitive | Easily absorbing moisture |
Refractive Index | 1.637 |
MDL | MFCD00017380 |
Physical and Chemical Properties | White crystalline powder, soluble in methanol, derived from Centella asiatica. |
Safety Description | 24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
RTECS | YU9555000 |
HS Code | 29389090 |
Reference Show more | 1. Zhao, Yun, et al. "Effect of centella asiatica on oxidative stress and lipid metabolism in hyperlipidemic animal models." Oxidative Medicine and Cellular Longevity 2014 (2014).https://doi.org/10.1155/2014/154295 2. [IF=6.543] Zhao Yun et al."Effect of Centella asiatica on Oxidative Stress and Lipid Metabolism in Hyperlipidemic Animal Models."Oxid Med Cell Longev. 2014;2014:154295 3. [IF=2.408] Amit Jaisi et al."Investigation of HIV-1 Viral Protein R Inhibitory Activities of Twelve Thai Medicinal Plants and Their Commercially Available Major Constituents."Chemistry & Biodiversity. 2021 Oct 27 |
biological activity | Madecassoside (Asiaticoside A) is the main active triterpene component of the herbal medicine of Cella asiatica, a traditional Chinese medicine used for wound repair and scar management. |
use | madecaside has the effects of anti-depression, burn scar, anti-cancer, prevention and treatment of coronary heart disease, myocardial infarction, cerebral thrombosis, cerebral infarction, enhancement of memory and whitening of skin. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: suitable for depression, burn scars, anti-cancer, prevention and treatment of coronary heart disease, myocardial infarction, cerebral thrombosis, cerebral infarction, enhance memory, skin whitening. |