349-76-8
3'-(Trifluoromethyl)acetophenone
CAS: 349-76-8
Molecular Formula: C9H7F3O
349-76-8 - Names and Identifiers
| Name | 3'-(Trifluoromethyl)acetophenone |
| Synonyms | 3-ACETYLBENZOFLUORIDE 3-ACETYLBENZOTRIFLUORIDE 3-Trifludromethylacetophen 3-trifluoromethylacetophenone 3'-trifluoromethylacetophenone 3-(Trifluoromethyl)acetophenone 3-nitrobenzenesulfonyl fluoride m-(Trifluoromethyl)acetophenone 3'-(Trifluoromethyl)acetophenone 3'-(TRIFLUOROMETHYL)ACETOPHENONE 3'-(Trifluoromethyl) acetophenone 1-[3-(trifluoromethyl)phenyl]ethanone 1-[3-(Trifluoromethyl)phenyl]-1-ethanone 1-[3-(Trifluoromethyl)phenyl]ethan-1-one, 3-Acetylbenzotrifluoride |
| CAS | 349-76-8 |
| EINECS | 206-490-4 |
| InChI | InChI=1/C6H4FNO4S/c7-13(11,12)6-3-1-2-5(4-6)8(9)10/h1-4H |
| InChIKey | ABXGMGUHGLQMAW-UHFFFAOYSA-N |
349-76-8 - Physico-chemical Properties
| Molecular Formula | C9H7F3O |
| Molar Mass | 188.15 |
| Density | 1.235g/mLat 25°C(lit.) |
| Boling Point | 198-200°C(lit.) |
| Flash Point | 183°F |
| Water Solubility | 620mg/L at 25℃ |
| Vapor Presure | 35Pa at 25℃ |
| Appearance | clear liquid |
| Specific Gravity | 1.235 |
| Color | Colorless to Red to Green |
| BRN | 640151 |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | n20/D 1.4611(lit.) |
| Physical and Chemical Properties | Colorless liquid |
| Use | Used as a pesticide intermediate |
349-76-8 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 1 |
| TSCA | Yes |
| HS Code | 29147090 |
| Hazard Class | IRRITANT |
349-76-8 - Reference Information
| LogP | 2.55 at 25℃ |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| synthesis and preparation method | m-trifluoromethyl acetophenone is an important organic synthesis intermediate, mainly used in medicine, pesticides and dyes and other fields. There are several laboratory synthesis methods as follows: 1. Grignter reaction of metrifluoromethylbenzoxane with methyl iodide. 2. Grigndall reaction of m-trifluoromethylbenzoic acid with methyl iodide after acyl chlorination. 3, m-trifluoromethyl benzaldehyde and diazomethane reaction. 4. The diazonium salt of m-trifluoromethylaniline reacts with acetaldehyde crotch. 5. The Grignard reagent of m-trifluoromethyl bromobenzene reacts with acetic anhydride (using trifluoromethyl benzene as raw material, after bromination, Grignard reaction and acetic anhydride reaction to synthesize m-trifluoromethyl acetophenone, the total yield is 40%). 1,2,3 methods The starting raw materials are expensive, the source is difficult, the yield is low, the risk is high, and it is not easy to industrialize. The nitrogen yield of the five items is too low, only about 40%. Yancheng Fluorosource Chemical Co., Ltd. has studied a new method to synthesize m-trifluoromethyl acetophenone through diazotization, coupling and hydrolysis with a total yield of 78%. |
| use | as pesticide intermediate |
Last Update：2024-04-09 02:00:05
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View History
349-76-8
148017-28-1
104-51-8
2-Bromo-6-fluorotoluene
1393477-72-9
148063-59-6
WYE-354
4-Bromo-2,6-difluorobenzonitrile
3,5-Dimethoxyphenylacetonitrile
1-(3-Methoxypropyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
148017-28-1
104-51-8
2-Bromo-6-fluorotoluene
1393477-72-9
148063-59-6
WYE-354
4-Bromo-2,6-difluorobenzonitrile
3,5-Dimethoxyphenylacetonitrile
1-(3-Methoxypropyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole