351344-10-0
Methyllycaconitine (citrate)
CAS: 351344-10-0
Molecular Formula: C43H58N2O17
351344-10-0 - Names and Identifiers
| Name | Methyllycaconitine (citrate) |
| Synonyms | METHYLLYCACONITINE CITRATE Methyllycaconitine (citrate) |
| CAS | 351344-10-0 |
351344-10-0 - Physico-chemical Properties
| Molecular Formula | C43H58N2O17 |
| Molar Mass | 874.93 |
| In vitro study | Pretreatment with 5 and 10 µM Methyllycaconitine citrate (MLA) inhibits the decreased cell viability induced by Aβ 25-35 . Cell viability does not decrease after exposure to Methyllycaconitine citrate (2.5, 5, 10, 20 µM). Aβ 25-35 treatment increases LC3-II levels, which is inhibited by administration of Methyllycaconitine citrate. Methyllycaconitine citrate also inhibits Aβ-induced autophagosome accumulation in SH-SY5Y cells. Flow cytometry also demonstrates decreased MDC-labeled vacuoles with Methyllycaconitine citrate treatment. |
| In vivo study | Methyllycaconitine citrate (MLA) (6 mg/kg) given alone intraperitoneally does not cause climbing behavior when compare with the saline group. Pretreatment with Methyllycaconitine citrate significantly inhibits methamphetamine (METH)-induced climbing behavior, by about 50%. Methyllycaconitine citrate does not modify either basal locomotor activity or METH-induced hyperlocomotion. The METH-induced depletion of dopamine neuron terminals is attenuated in mice pretreated with Methyllycaconitine citrate (250±43 fmol/mg, n=7). A direct effect of Methyllycaconitine citrate on body temperature is ruled out because Methyllycaconitine citrate does not affect basal body temperature (37.0±0.5°C, n=5) or reduce the METH-induced hyperthermia (38.2±0.4°C, n=6, MLA+METH group, n.s. versus METH group). |
351344-10-0 - References
| biological activity | methyllylccaconitine citrate is a specific antagonist of the α7 neuronal nicotinic acetylcholine receptor (α7nAChR). |
| Target | α7nAChR |
Last Update：2024-04-09 02:00:20
